识别记忆和内侧颞叶遗忘的动物模型：历史和当前问题。
An animal model of recognition memory and medial temporal lobe amnesia: history and current issues.
机构信息
Veterans Affairs Medical Center, San Diego, 92161, USA.
出版信息
Neuropsychologia. 2010 Jul;48(8):2234-44. doi: 10.1016/j.neuropsychologia.2010.02.004. Epub 2010 Feb 7.
Abstract
The medial temporal lobe includes a system of anatomically connected structures that are essential for declarative memory (conscious memory for facts and events). A prominent form of declarative memory is recognition memory (the ability to identify a recently encountered item as familiar). Recognition memory has been frequently assessed in humans and in the experimental animal. This article traces the successful development of an animal model of human medial temporal lobe amnesia, which eventually identified the structures in the medial temporal lobe important for memory. Attention is given to two prominent behavioral paradigms (delayed nonmatching to sample and tests of spontaneous novelty preference).
摘要
内侧颞叶包括一个在解剖上相互连接的结构系统，对于陈述性记忆（对事实和事件的有意识记忆）至关重要。陈述性记忆的一种突出形式是识别记忆（识别最近遇到的项目是否熟悉的能力）。识别记忆已在人类和实验动物中得到广泛评估。本文追溯了人类内侧颞叶遗忘动物模型的成功发展，该模型最终确定了内侧颞叶中对记忆重要的结构。本文重点介绍了两个突出的行为范式（延迟不匹配样本和自发新颖性偏好测试）。
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