Hou Fei-Fei, Wang Bei-Bei, Chen Ye, Wang Qiong, Wu Qiong, Yan Li-Na
Department of Intensive Care Unit, Inner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Department of Cardiology, The First People's Hospital of Jinzhong, Jinzhong, Shanxi, People's Republic of China.
Eur J Med Res. 2024 Dec 31;29(1):641. doi: 10.1186/s40001-024-02246-z.
High triglyceride (TG) levels are important risk factors for cardiovascular disease (CVD). Some recent studies have shown that snoring is also closely related to elevated TG levels. The specific pathogenesis of elevated TG levels in snoring patients is still unclear. Therefore, we performed this meta-analysis to evaluate the relationship between snoring and elevated TG levels.
A systematic search was conducted in four online electronic databases as of Jul 1, 2024. The standardized mean difference (SMD) and corresponding 95% confidence interval (CI) for TG levels in each study were pooled. Moreover, we performed subgroup analysis according to snoring status and body mass index (BMI). All the data were pooled and analysed with Review Manager 5.3.
The meta-analysis included five studies with 39,102 participants. Our results revealed that snoring was associated with elevated TG levels, with a pooled SMD of 0.23 (95% CI 0.14 to0.32; P < 0.00001). We found that occasional snoring and habitual snoring were associated with high TG levels, with pooled SMD of 0.26 (95% CI 0.04to0.49; P = 0.002) and 0.29 (95% CI 0.16to0.43; P < 0.0001), respectively. According to the subgroup analysis of BMI, BMI < 25 kg/m and BMI ≥ 25 kg/m were associated with increased TG levels, with pooled SMD of 0.13 (95% CI 0.04 to 0.22; P = 0.004) and 0.24 (95% CI 0.10 to 0.39; P = 0.0007), respectively.
Our meta-analysis revealed that both occasional and habitual snoring were associated with elevated TG levels. More importantly, our findings also revealed that the relationship between snoring-induced elevated TG levels and BMI was fragile.
高甘油三酯（TG）水平是心血管疾病（CVD）的重要危险因素。最近的一些研究表明，打鼾也与TG水平升高密切相关。打鼾患者TG水平升高的具体发病机制仍不清楚。因此，我们进行了这项荟萃分析，以评估打鼾与TG水平升高之间的关系。
截至2024年7月1日，在四个在线电子数据库中进行了系统检索。汇总了每项研究中TG水平的标准化平均差（SMD）和相应的95%置信区间（CI）。此外，我们根据打鼾状态和体重指数（BMI）进行了亚组分析。所有数据均汇总并使用Review Manager 5.3进行分析。
荟萃分析纳入了五项研究，共39102名参与者。我们的结果显示，打鼾与TG水平升高相关，汇总SMD为0.23（95%CI 0.14至0.32；P < 0.00001）。我们发现偶尔打鼾和习惯性打鼾均与高TG水平相关，汇总SMD分别为0.26（95%CI 0.04至0.49；P = 0.002）和0.29（95%CI 0.16至0.43；P < 0.0001）。根据BMI亚组分析，BMI<25kg/m和BMI≥25kg/m均与TG水平升高相关，汇总SMD分别为0.13（95%CI 0.04至0.22；P = 0.004）和0.24（95%CI 0.10至0.39；P = 0.0007）。
我们的荟萃分析表明，偶尔打鼾和习惯性打鼾均与TG水平升高相关。更重要的是，我们的研究结果还表明，打鼾引起的TG水平升高与BMI之间的关系并不稳定。
