Archibong Efiok Aniekan, Beshel Justin Atiang, Okon Idara Asuquo, Ikum Glory Aidam, Anaba Stella Chiamaka, Owu Daniel Udofia
College of Korean Medicine, Woosuk University, Wanju, Republic of Korea.
Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
J Pharmacopuncture. 2024 Dec 31;27(4):297-307. doi: 10.3831/KPI.2024.27.4.297.
This study assessed the electrocardiographic pattern and cardiac inflammatory response of doxorubicin-induced myocardial injury in Wistar rats treated with ethanol extract.
Female Wistar rats (190-200 g) were assigned into five groups of seven rats each. The Group 1 (Control group) was given rat chow and drinking water while the Group 2 (doxorubicin group) received intraperitoneal administration of doxorubicin (2 mg/kg) once weekly for three weeks. The Group 3 ( group) received 200 mg/kg of ethanolic extract of daily. Group 4 (Doxorubicin + group) received doxorubicin in addition to Group 5 (Captopril (50 mg/kg) was administered to another group in addition to while the doxorubicin + captopril group was administered captopril in addition to doxorubicin. Electrical recording and cardiac markers were evaluated.
The results revealed a significant (p < 0.01) elevation of T-wave and altered electrocardiographic parameters in the doxorubicin group than the control, , and other experimental groups. The heart rate, cardiac troponin level, lactate dehydrogenase, creatine kinase, angiotensin-converting enzyme activities, and inflammatory biomarkers were significantly (p < 0.01) higher while nitric oxide level was significantly (p < 0.05) reduced in the doxorubicin-only group compared to the control. Cardiac cell hypertrophy and inflammatory cell infiltration were observed due to doxorubicin administration. Treatment with extract and captopril reversed these trends and improved the antioxidants and inflammatory activities.
extract improves electrocardiographic pattern, has cardioprotective ability, and prevents doxorubicin-induced myocardial injury probably due to its phytochemical constituents and anti-inflammatory properties.
本研究评估了用乙醇提取物处理的Wistar大鼠中阿霉素诱导的心肌损伤的心电图模式和心脏炎症反应。
将雌性Wistar大鼠（190 - 200克）分为五组，每组七只。第1组（对照组）给予大鼠饲料和饮用水，而第2组（阿霉素组）每周一次腹腔注射阿霉素（2毫克/千克），共三周。第3组（[提取物名称]组）每天接受200毫克/千克的[提取物名称]乙醇提取物。第4组（阿霉素 + [提取物名称]组）除[提取物名称]外还接受阿霉素，第5组（卡托普利组）除[提取物名称]外还给予卡托普利（50毫克/千克），而阿霉素 + 卡托普利组除阿霉素外还给予卡托普利。评估电记录和心脏标志物。
结果显示，与对照组、[提取物名称]组和其他实验组相比，阿霉素组的T波显著升高（p < 0.01）且心电图参数改变。与对照组相比，仅阿霉素组的心率、心肌肌钙蛋白水平、乳酸脱氢酶、肌酸激酶、血管紧张素转换酶活性和炎症生物标志物显著升高（p < 0.01），而一氧化氮水平显著降低（p < 0.05）。由于给予阿霉素，观察到心脏细胞肥大和炎症细胞浸润。用[提取物名称]提取物和卡托普利治疗可逆转这些趋势，并改善抗氧化和炎症活性。
[提取物名称]提取物改善心电图模式，具有心脏保护能力，并可能因其植物化学成分和抗炎特性预防阿霉素诱导的心肌损伤。
