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脑脊液线粒体N-甲酰甲硫氨酸肽作为抗N-甲基-D-天冬氨酸受体脑炎和抗富含亮氨酸胶质瘤失活蛋白1脑炎的辅助诊断工具

CSF Mitochondrial N-Formyl Methionine Peptide as Complementary Diagnostic Tool in Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis.

作者信息

Li Chuo, Chen Jun-Yu, Peng Yu, Wang Hong-Hao, Zheng Dong, Wang Yuan-Yuan

机构信息

Department of Neurology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510440, People's Republic of China.

Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangdong, 510370, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2024 Dec 27;20:2629-2636. doi: 10.2147/NDT.S482616. eCollection 2024.

DOI:10.2147/NDT.S482616
PMID:39741905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11687102/
Abstract

BACKGROUND

Mitochondrial damage is significant in autoimmune diseases, with mitochondrial N-formyl methionine peptide (fMet) being released from damaged mitochondria. However, its potential as a marker for assessing the severity of two kinds of encephalitis - anti-N-methyl-D-aspartate receptor (anti-NMDAR) and anti-leucine-rich glioma-inactivated 1 (LGI1) - remains uncertain. We measured CSF fMet levels in anti-NMDAR encephalitis and anti-LG1 encephalitis patients, assessing its diagnostic and therapeutic potential.

METHODS

Twenty-five patients diagnosed with anti-NMDAR encephalitis and nineteen patients with anti-LGI1 encephalitis were included in the study. Their cerebrospinal fluid (CSF) fMet levels were assessed using enzyme-linked immunosorbent assays.

RESULTS

The findings revealed a significant increase in CSF fMet levels, which correlated with modified Rankin Scale (mRS) scores in both anti-NMDAR encephalitis and anti-LGI1 encephalitis patients.

CONCLUSION

The CSF fMet levels were found to be associated with disease severity in patients diagnosed with both anti-NMDAR encephalitis and anti-LGI1 encephalitis. These findings suggest that preventing mitochondrial damage could serve as an effective treatment strategy for managing these diseases.

摘要

背景

线粒体损伤在自身免疫性疾病中很显著，线粒体N - 甲酰甲硫氨酸肽（fMet）会从受损线粒体中释放出来。然而，其作为评估两种脑炎——抗N - 甲基 - D - 天冬氨酸受体（抗NMDAR）脑炎和抗富含亮氨酸胶质瘤失活1（LGI1）脑炎严重程度标志物的潜力仍不确定。我们测量了抗NMDAR脑炎和抗LGI1脑炎患者脑脊液中的fMet水平，评估其诊断和治疗潜力。

方法

本研究纳入了25例诊断为抗NMDAR脑炎的患者和19例抗LGI1脑炎患者。使用酶联免疫吸附测定法评估他们脑脊液中的fMet水平。

结果

研究结果显示，抗NMDAR脑炎和抗LGI1脑炎患者脑脊液中的fMet水平显著升高，且与改良Rankin量表（mRS）评分相关。

结论

在诊断为抗NMDAR脑炎和抗LGI1脑炎的患者中，脑脊液fMet水平与疾病严重程度相关。这些发现表明，预防线粒体损伤可能是治疗这些疾病的有效策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64e/11687102/36b6f630f4ec/NDT-20-2629-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64e/11687102/6e63850fbd1d/NDT-20-2629-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64e/11687102/36b6f630f4ec/NDT-20-2629-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64e/11687102/6e63850fbd1d/NDT-20-2629-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d64e/11687102/36b6f630f4ec/NDT-20-2629-g0002.jpg

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本文引用的文献

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Mitochondrial N-formyl methionine peptides associate with disease activity as well as contribute to neutrophil activation in patients with rheumatoid arthritis.线粒体 N-甲酰甲硫氨酸肽与疾病活动相关，并有助于类风湿关节炎患者中性粒细胞的激活。
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抗体阳性自身免疫性脑炎患者急性脑脊液异常的预后价值。
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Elevated Serum and Cerebrospinal Fluid CD138 in Patients With Anti--Methyl-d-Aspartate Receptor Encephalitis.抗N-甲基-D-天冬氨酸受体脑炎患者血清和脑脊液中CD138升高
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Cell-Free Mitochondrial DNA in the CSF: A Potential Prognostic Biomarker of Anti-NMDAR Encephalitis.脑脊液中的无细胞线粒体 DNA：抗 NMDAR 脑炎的潜在预后生物标志物。
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Development of the clinical assessment scale in autoimmune encephalitis.自身免疫性脑炎临床评估量表的制定。
Ann Neurol. 2019 Mar;85(3):352-358. doi: 10.1002/ana.25421. Epub 2019 Feb 10.
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Mitochondria in innate immune signaling.线粒体在先天免疫信号中的作用。
Transl Res. 2018 Dec;202:52-68. doi: 10.1016/j.trsl.2018.07.014. Epub 2018 Aug 7.
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Antibody-Mediated Encephalitis.抗体介导的脑炎
N Engl J Med. 2018 Mar 1;378(9):840-851. doi: 10.1056/NEJMra1708712.
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