血清中性粒细胞明胶酶相关脂质运载蛋白在急性心力衰竭中的预后价值：一项荟萃分析
Prognostic Value of Serum Neutrophil Gelatinase-Associated Lipocalin in Acute Heart Failure: A Meta-Analysis.
作者信息
Cheng Zhendong, Lin Xiaoxin, Xu Chaoxiang, Zhang Zhilong, Lin Naping, Cai Kefeng
机构信息
Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, 362000 Quanzhou, Fujian, China.
出版信息
Rev Cardiovasc Med. 2024 Nov 29;25(12):428. doi: 10.31083/j.rcm2512428. eCollection 2024 Dec.
BACKGROUND
Neutrophil gelatinase-associated lipocalin (NGAL) is not only a sensitive marker of acute kidney injury but may also be a prognostic marker of acute heart failure (AHF). This study aimed to investigate the relationship between serum NGAL and all-cause death (ACD) and the composite outcome of ACD or AHF readmissions in patients with AHF.
METHODS
The Embase, Cochrane Library, and PubMed databases were searched for articles focusing on serum NGAL and ACD and the composite outcome of ACD or AHF readmissions in patients with AHF. The hazard ratios (HRs) were pooled with random-effects models.
RESULTS
The results from 2428 patients from seven studies were pooled in this article. Higher NGAL was relevant to an increased risk of ACD (HR, 1.89; 95% CI, 1.38 to 2.61) and the composite outcome of ACD or AHF readmissions (HR, 2.92; 95% CI, 1.62 to 5.27) in patients with AHF.
CONCLUSIONS
Serum NGAL has prognostic value for ACD and the composite outcome of ACD or AHF readmissions in AHF.
THE PROSPERO REGISTRATION
CRD42022322057, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322057.
背景
中性粒细胞明胶酶相关脂质运载蛋白（NGAL）不仅是急性肾损伤的敏感标志物，还可能是急性心力衰竭（AHF）的预后标志物。本研究旨在探讨AHF患者血清NGAL与全因死亡（ACD）以及ACD或AHF再入院的复合结局之间的关系。
方法
检索Embase、Cochrane图书馆和PubMed数据库，查找关注AHF患者血清NGAL与ACD以及ACD或AHF再入院复合结局的文章。采用随机效应模型汇总风险比（HRs）。
结果
本文汇总了来自7项研究的2428例患者的结果。较高的NGAL与AHF患者ACD风险增加（HR，1.89；95%CI，1.38至2.61）以及ACD或AHF再入院的复合结局（HR，2.92；95%CI，1.62至5.27）相关。
结论
血清NGAL对AHF患者的ACD以及ACD或AHF再入院的复合结局具有预后价值。
PROSPERO注册号：CRD42022322057，https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322057 。
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