Jones R B, Whitney R G, Smith J R
Mech Ageing Dev. 1985 Feb;29(2):143-9. doi: 10.1016/0047-6374(85)90014-4.
A series of mitotic pairs of cells were isolated and the proliferative potential of each cell determined. Although the proliferative potentials of the two cells of a single pair were similar for most pairs examined, in a significant proportion large differences were observed. These results suggest a strong stochastic component in the somatic inheritance of proliferative potential. This observation provides the basis for refinement of a mathematical model for in vitro cellular aging.
分离出一系列处于有丝分裂期的细胞对，并测定每个细胞的增殖潜力。尽管在大多数检测的细胞对中，单个细胞对中的两个细胞的增殖潜力相似，但仍有相当比例观察到了较大差异。这些结果表明，增殖潜力的体细胞遗传中存在强大的随机成分。这一观察结果为完善体外细胞衰老的数学模型提供了基础。
