Wu Yung-Chun, Lian Yu Zhi, Zhao Hongwei, Wang Lei, Ning Deshan, Chao Jane C-J
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan.
Infinitus (China) Company Ltd., Guangzhou 510405, China.
Int J Med Sci. 2025 Jan 1;22(1):17-26. doi: 10.7150/ijms.99889. eCollection 2025.
Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remain unknown. Hence, the effects of Chinese herb powder (CHP) which consisted of bioactive compounds such as ginsenosides (Rg1, Re, and Rb1), salidroside, and syringin on exercise performance, energy metabolism, tissue damage, antioxidant activity, and inflammatory cytokine were investigated in exhaustive exercise rats. Male Sprague-Dawley rats aged of 8-week-old were randomly assigned into four groups: control (normal, N), low-dose (L, 310 mg/kg bw), medium-dose (M, 620 mg/kg bw), and high-dose (H, 1550 mg/kg bw) groups. The intervention groups were orally given CHP daily for successive 30 days. Abdominal arterial blood, liver, and gastrocnemius muscles were collected 4 hours after exhaustive exercise for further analysis. The high-dose CHP group increased the time to exhaustion, decreased serum lactate level, increased serum superoxide dismutase activity, and decreased liver interleukin-6 concentration. Therefore, CHP exhibits an anti-fatigue effect for prolonging the time to exhaustion through improving lactate clearance, and to a lesser extent, enhancing the capacity of antioxidation and anti-inflammation.
过度运动可导致疲劳，进而影响运动表现，并进一步对人体健康产生不利影响。人参皂苷、红景天苷和紫丁香苷对提高运动表现的协同作用尚不清楚。因此，本研究在力竭运动大鼠中探究了由人参皂苷（Rg1、Re和Rb1）、红景天苷和紫丁香苷等生物活性化合物组成的中药粉（CHP）对运动表现、能量代谢、组织损伤、抗氧化活性和炎性细胞因子的影响。将8周龄的雄性Sprague-Dawley大鼠随机分为四组：对照组（正常组，N）、低剂量组（L，310 mg/kg体重）、中剂量组（M，620 mg/kg体重）和高剂量组（H，1550 mg/kg体重）。干预组连续30天每天口服CHP。力竭运动4小时后采集腹主动脉血、肝脏和腓肠肌用于进一步分析。高剂量CHP组延长了力竭时间，降低了血清乳酸水平，提高了血清超氧化物歧化酶活性，并降低了肝脏白细胞介素-6浓度。因此，CHP通过改善乳酸清除，在较小程度上增强抗氧化和抗炎能力，表现出抗疲劳作用，可延长力竭时间。
