Kim Do Hyun, Hwang Se Hwan
Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Otolaryngology-Head and Neck Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
J Rhinol. 2024 Nov;31(3):133-137. doi: 10.18787/jr.2024.00030. Epub 2024 Nov 30.
Mesenchymal stem cells (MSCs) are multipotent progenitor cells present in adult tissues that are recognized as promising candidates for cell therapy due to their ease of access, straightforward isolation, and capacity for bio-preservation with minimal loss of potency. However, the clinical application of MSCs faces significant challenges, such as donor site morbidity, underscoring the need for alternative sources. Recent studies have suggested that inferior turbinate tissues, which are commonly removed during turbinate surgery, may be a viable donor site for MSCs. Turbinate surgery is a safe and effective procedure frequently performed to alleviate nasal obstruction, a prevalent chronic condition treated by otolaryngologists. This implies that harvesting MSCs from turbinate tissue for tissue engineering and regenerative medicine could serve as a simple, minimally invasive method with faster healing and minimal risk of morbidity or scarring at the donor site. This review highlights previous research indicating that MSCs derived from human turbinate tissues maintain their stability and demonstrate multi-differentiation potential. Therefore, the turbinate could be an alternative to traditional MSC sources for producing functionally competent cells for future clinical applications.
间充质干细胞（MSCs）是存在于成体组织中的多能祖细胞，因其易于获取、分离简便且在生物保存时活力损失最小，而被视为细胞治疗的有前景的候选者。然而，MSCs的临床应用面临重大挑战，如供体部位的并发症，这凸显了寻找替代来源的必要性。最近的研究表明，在下鼻甲手术中通常会被切除的下鼻甲组织，可能是MSCs的一个可行的供体部位。下鼻甲手术是一种安全有效的手术，经常用于缓解鼻阻塞，这是耳鼻喉科医生治疗的一种常见慢性病。这意味着从下鼻甲组织中获取MSCs用于组织工程和再生医学，可以作为一种简单、微创的方法，具有更快的愈合速度，且供体部位发病或形成瘢痕的风险最小。这篇综述强调了先前的研究，表明源自人下鼻甲组织的MSCs保持其稳定性并具有多分化潜能。因此，下鼻甲可以替代传统的MSCs来源，为未来的临床应用生产功能健全的细胞。
