Fu Qinrui, Fu Lejun
Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao University, Qingdao University, Jinan 250014, China.
Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, China.
Theranostics. 2025 Jan 1;15(2):439-459. doi: 10.7150/thno.102626. eCollection 2025.
Reproductive health-related diseases have a significant impact on the well-being of millions of women worldwide, severely compromising their quality of life. Women encounter unique challenges in terms of reproductive health, including gynecological diseases and malignant neoplasms prior to pregnancy, as well as complications during pregnancy that greatly undermine their physical and mental health. Despite recent advancements in the field of female reproduction, substantial challenges still persist. To address these challenges, nanotechnology-based diagnostic and therapeutic strategies have emerged to provide intelligent detection and treatment for pathologies related to women's reproductive health. Although some progress has been made with nanotherapeutics in this domain, its application is still nascent due to the delicate and intricate nature of the female reproductive system. This review comprehensively presents the latest advancements in nanomedicine for regulating woman's reproductive health. Firstly, based on the time period of onset, nanomedicine applications are categorized into four subcategories: 1) preconception diseases such as polycystic ovary syndrome, endometriosis, and gynecologic malignancy treatment; 2) pregastrulation period diseases including placenta accreta spectrum disorders and ectopic pregnancy; 3) mid-term pregnancy diseases like preeclampsia; and 4) late pregnancy diseases such as deep vein thrombosis during pregnancy. The systematic introduction covers the progress made by nanomedicine in various disease areas. Finally, this article discusses the challenges faced by these nanomedicines from research to clinical translation while also highlighting future directions.
与生殖健康相关的疾病对全球数百万女性的健康产生重大影响，严重损害她们的生活质量。女性在生殖健康方面面临独特挑战，包括孕前的妇科疾病和恶性肿瘤，以及孕期并发症，这些都极大地损害了她们的身心健康。尽管女性生殖领域最近取得了进展，但重大挑战仍然存在。为应对这些挑战，基于纳米技术的诊断和治疗策略应运而生，为与女性生殖健康相关的病症提供智能检测和治疗。尽管纳米疗法在这一领域已取得一些进展，但由于女性生殖系统的精细和复杂性质，其应用仍处于初期阶段。本综述全面介绍了纳米医学在调节女性生殖健康方面的最新进展。首先，根据发病时间，将纳米医学应用分为四个子类别：1）孕前疾病，如多囊卵巢综合征、子宫内膜异位症和妇科恶性肿瘤治疗；2）原肠胚形成前期疾病，包括胎盘植入谱系障碍和异位妊娠；3）中期妊娠疾病，如子痫前期；4）晚期妊娠疾病，如孕期深静脉血栓形成。系统介绍涵盖了纳米医学在各个疾病领域取得的进展。最后，本文讨论了这些纳米药物从研究到临床转化所面临的挑战，同时也强调了未来的方向。
