Neurotensin signaling in fat modulates food intake.
作者信息
Jang YoungUk, Rajbhandari Prashant
机构信息
Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Cell Res. 2025 Feb;35(2):85-86. doi: 10.1038/s41422-024-01048-6.
Abstract
摘要
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Neurotensin signaling in fat modulates food intake.脂肪中的神经降压素信号传导调节食物摄入。
Cell Res. 2025 Feb;35(2):85-86. doi: 10.1038/s41422-024-01048-6.
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Changes in hypothalamic neurotensin concentrations and food intake in rats fed a high fat diet.高脂饮食喂养大鼠下丘脑神经降压素浓度及食物摄入量的变化
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Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging.神经降压素抑制肥胖和衰老相关的小肠上皮细胞中的AMPK活性，并同时增强脂肪酸结合蛋白1（FABP1）的表达。
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Peripheral and central administration of xenin and neurotensin suppress food intake in rodents.向啮齿动物外周和中枢给予 Xenin 和神经降压素可抑制食物摄入。
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Opposite influence of carbohydrates and fat on hypothalamic neurotensin in Long-Evans rats.碳水化合物和脂肪对长-伊文斯大鼠下丘脑神经降压素的相反影响。
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The effect of neurotensin on food consumption in the rat.神经降压素对大鼠食物摄取的影响。
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Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient Mice.垂直袖状胃切除术后诱导的厌食和脂肪厌恶在神经降压素受体1缺陷小鼠中减弱。
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Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice.神经降压素受体1缺陷型小鼠中瘦素的厌食作用受损。
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本文引用的文献
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Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity.整合应激反应调节脂肪细胞中生长分化因子15（GDF15）的分泌，优先抑制对高脂饮食的食欲并改善肥胖。
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Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.神经降压素是由淋巴管内皮细胞产生的一种抗热敏肽。
Cell Metab. 2021 Jul 6;33(7):1449-1465.e6. doi: 10.1016/j.cmet.2021.04.019. Epub 2021 May 25.
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Ceramides and other sphingolipids as drivers of cardiovascular disease.神经酰胺和其他鞘脂类作为心血管疾病的驱动因素。
Nat Rev Cardiol. 2021 Oct;18(10):701-711. doi: 10.1038/s41569-021-00536-1. Epub 2021 Mar 26.
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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.GDF15 在小鼠和人类中提供营养应激的内分泌信号。
Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.
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Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.肥胖诱导的 CerS6 依赖性 C16:0 神经酰胺产生促进体重增加和葡萄糖不耐受。
Cell Metab. 2014 Oct 7;20(4):678-86. doi: 10.1016/j.cmet.2014.08.002.
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Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.鞘脂、胰岛素抵抗与代谢性疾病：鞘脂代谢体内调控的新见解
Endocr Rev. 2008 Jun;29(4):381-402. doi: 10.1210/er.2007-0025. Epub 2008 May 1.
7
Principles of bioactive lipid signalling: lessons from sphingolipids.生物活性脂质信号传导原理：来自鞘脂类的经验教训。
Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50. doi: 10.1038/nrm2329.
8
Neurotensin metabolism in various tissues of central and peripheral origins: ubiquitous involvement of a novel neurotensin degrading metalloendopeptidase.中枢和外周来源的各种组织中的神经降压素代谢：一种新型神经降压素降解金属内肽酶的普遍参与
Biochimie. 1988 Jan;70(1):75-82. doi: 10.1016/0300-9084(88)90161-7.
9
High-affinity receptor sites and rapid proteolytic inactivation of neurotensin in primary cultured neurons.原代培养神经元中神经降压素的高亲和力受体位点及快速蛋白水解失活
J Neurochem. 1986 Dec;47(6):1742-8. doi: 10.1111/j.1471-4159.1986.tb13083.x.
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