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一名两岁儿童患布加综合征和川崎病：双重风险病例

Brugada Syndrome and Kawasaki Disease in a Two-Year-Old: A Case of Double Jeopardy.

作者信息

Boateng Jeffery O, Stein Ilana, Hidalgo Nicholas

机构信息

Pediatrics, St. Barnabas Hospital Health System, Bronx, USA.

Pediatric Cardiology, Children's Hospital at Montefiore, Bronx, USA.

出版信息

Cureus. 2024 Dec 2;16(12):e75001. doi: 10.7759/cureus.75001. eCollection 2024 Dec.

DOI:10.7759/cureus.75001
PMID:39749072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11693925/
Abstract

Brugada syndrome (BrS) is a genetic channelopathy that may predispose to ventricular arrhythmia. It is inherited as an autosomal dominant pattern with incomplete penetrance. Fever can unmask Brugada syndrome in children who have a genetic predisposition. Kawasaki disease is not known to be associated with Brugada syndrome; however, it may lead to cardiac complications such as coronary artery abnormalities and myocardial inflammation. We report a case of a two-year-old who was diagnosed with Kawasaki disease and subsequently developed Brugada syndrome.

摘要

布加综合征（BrS）是一种遗传性离子通道病，可能易患室性心律失常。它以常染色体显性模式遗传，具有不完全外显率。发热可使具有遗传易感性的儿童显现出布加综合征。目前已知川崎病与布加综合征无关；然而，它可能导致心脏并发症，如冠状动脉异常和心肌炎症。我们报告一例两岁患儿，其最初被诊断为川崎病，随后发展为布加综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f30e/11693925/0a5e968b70c9/cureus-0016-00000075001-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f30e/11693925/0a5e968b70c9/cureus-0016-00000075001-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f30e/11693925/0a5e968b70c9/cureus-0016-00000075001-i01.jpg

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Cardiovascular Involvement in Kawasaki Disease Is Much More Than Mere Coronary Arteritis.川崎病中的心血管受累远不止单纯的冠状动脉炎。
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Fever-Induced Brugada-Pattern Electrocardiogram.发热诱发 Brugada 波型心电图。
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Kawasaki disease.川崎病
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Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent.导致Brugada综合征心电图表型的离子机制是温度依赖性的。
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