Inoue H, Kohsaka S, Yoshida K, Ohtani M, Toya S, Tsukada Y
Neurosci Lett. 1985 Feb 28;54(1):85-90. doi: 10.1016/s0304-3940(85)80122-1.
The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.
研究了免疫抑制剂环孢素A对移植到成年大鼠第三脑室的新生小鼠大脑皮质存活率的影响。苏木精染色显示，对照组移植后4周移植的小鼠脑组织被排斥。相比之下，在环孢素A治疗组中，即使在移植后4周，仍能在第三脑室清楚地检测到大量移植组织，并且移植组织被Thy-1.2小鼠单克隆抗体重度染色。结果表明，环孢素A在神经移植以及其他器官移植中是一种有效的免疫抑制剂。
