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探索腹腔镜减肥手术后恶心呕吐的发生率及影响因素:一项回顾性观察研究方案

Exploring the incidence and influencing factors of postoperative nausea and vomiting after laparoscopic bariatric surgery: a protocol for a retrospective observational study.

作者信息

Tan Juan, Liu Haibei, Tan Lin, Fu Qiang

机构信息

Department of Anesthesiology, Southwest Jiaotong University, the Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

出版信息

BMJ Open. 2025 Jan 2;15(1):e093929. doi: 10.1136/bmjopen-2024-093929.

Abstract

INTRODUCTION

The global prevalence of obesity and its associated comorbidities is rising, with bariatric surgery emerging as a highly efficacious intervention for obese patients. Postoperative nausea and vomiting (PONV) is a common complication following bariatric surgery, with a standardised protocol for its prevention and management yet to be established. This study aims to determine the incidence and the influencing factors of PONV following various types of bariatric surgeries, thereby facilitating the targeted prevention strategies.

METHODS AND ANALYSIS

This retrospective, single-centre observational study will be conducted at the Third People's Hospital of Chengdu, with an expected enrolment of 2500 patients who have undergone laparoscopic bariatric surgery from December 2019 to April 2024. The study aims to collect data regarding the incidence of PONV and analyse the potential risk and protective factors associated with its development in this patient population.

ETHICS AND DISSEMINATION

The study has been approved by the ethics committees of the Third People's Hospital of Chengdu. Given the retrospective nature of the study, informed consent was waived by the ethics committee, and all patient data were anonymised to safeguard privacy prior to the study authors' visit. The results of this study will be presented at various academic and healthcare conferences, spanning local to international levels and will also be submitted for publication in reputable, peer-reviewed journals.

TRIAL REGISTRATION NUMBER

This study has been registered with the Chinese Clinical Trial Register (ChiCTR) under registration number ChiCTR2400088738.

摘要

引言

全球肥胖及其相关合并症的患病率正在上升,减肥手术已成为肥胖患者一种高效的干预措施。术后恶心呕吐(PONV)是减肥手术后的常见并发症,其预防和管理的标准化方案尚未确立。本研究旨在确定各类减肥手术后PONV的发生率及其影响因素,从而推动针对性预防策略的制定。

方法与分析

本项回顾性、单中心观察性研究将在成都市第三人民医院开展,预计纳入2500例于2019年12月至2024年4月期间接受腹腔镜减肥手术的患者。该研究旨在收集有关PONV发生率的数据,并分析该患者群体中与其发生相关的潜在风险和保护因素。

伦理与传播

本研究已获得成都市第三人民医院伦理委员会的批准。鉴于本研究的回顾性性质,伦理委员会豁免了知情同意,且在研究作者访问之前,所有患者数据均已匿名化以保护隐私。本研究结果将在从地方到国际各级的各类学术和医疗会议上公布,也将提交至知名同行评审期刊发表。

试验注册号

本研究已在中国临床试验注册中心(ChiCTR)注册,注册号为ChiCTR2400088738。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e11d/11748921/bf4f430ff8d2/bmjopen-15-1-g001.jpg

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