Tura Teferi, Tamiru Yobsan, Dima Chala, Garoma Abebe, Kebede Abriham, Abdeta Debela
School of Veterinary Medicine, Wallaga University, Nekemte, Ethiopia.
Serology laboratory, Animal Health Institute, Sebeta, Ethiopia.
Sci Rep. 2025 Jan 4;15(1):812. doi: 10.1038/s41598-024-80602-z.
Bovine viral diarrhea (BVD) is a highly infectious disease affecting cattle, leading to significant economic losses in many countries engaged in cattle production. From February 2022 to October 2022, a study was conducted to determine the seroprevalence and associated risk factors of Bovine Viral Diarrhea Virus (BVDV) in the Sebeta subcity area of Sheger city, Ethiopia. The study utilized a semi-structured questionnaire to gather information on herd management practices from dairy farm owners. Serum samples from 170 individual cattle across 34 herds were collected and tested for BVDV antibodies using the indirect enzyme-linked immunosorbent assay (ELISA). The prevalence of BVD antibodies at both the animal and herd levels was analyzed, and potential risk factors were identified using Chi-square analysis and logistic regression. The study found that 19.41% of individual cattle (33 out of 170) and 44.12% of herds were positive for BVDV antibodies. Multiple logistic regression analysis identified several significant risk factors associated with BVDV infection. Multiparous dairy cows were found to be 2.3 times more likely to be seropositive compared to primiparous and nulliparous cows. Crossbreed dairy cattle had double the odds of being seropositive compared to pure breeds. Additionally, cattle from larger herds were 5.01 times more likely to be seropositive than those from smaller herds. Farms that introduced new animals had triple the odds of seropositivity compared to those that did not. The study indicates a high exposure rate of cattle to BVDV infection in and around Sebeta sub-city. Further research is recommended to explore the molecular epidemiology of BVDV in the region.
牛病毒性腹泻（BVD）是一种影响牛群的高度传染性疾病，在许多从事养牛业的国家造成了重大经济损失。2022年2月至2022年10月，在埃塞俄比亚谢格尔市塞贝塔分区开展了一项研究，以确定牛病毒性腹泻病毒（BVDV）的血清流行率及相关风险因素。该研究采用半结构化问卷，从奶牛场主那里收集有关畜群管理做法的信息。采集了来自34个牛群的170头个体牛的血清样本，并使用间接酶联免疫吸附测定（ELISA）检测BVDV抗体。分析了动物和畜群层面BVD抗体的流行情况，并使用卡方分析和逻辑回归确定潜在风险因素。研究发现，19.41%的个体牛（170头中的33头）和44.12%的牛群BVDV抗体呈阳性。多元逻辑回归分析确定了几个与BVDV感染相关的重要风险因素。与初产和未产奶牛相比，经产奶牛血清呈阳性的可能性高2.3倍。与纯种奶牛相比，杂交奶牛血清呈阳性的几率翻倍。此外，来自大畜群的牛血清呈阳性的可能性是来自小畜群的牛的5.01倍。引入新动物的农场血清阳性几率是未引入新动物农场的三倍。该研究表明，塞贝塔分区及其周边地区的牛群BVDV感染暴露率很高。建议进一步开展研究，以探索该地区BVDV的分子流行病学。
