Shahin Sarvenaz, Ghassabian Akhgar, Blaauwendraad Sophia M, Duh-Leong Carol, Kannan Kurunthachalam, Long Sara E, Herrera Teresa, Seok Eunsil, Pierce Kristyn A, Liu Mengling, Trasande Leonardo
Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States.
Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States; Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States.
Environ Res. 2025 Mar 1;268:120756. doi: 10.1016/j.envres.2025.120756. Epub 2025 Jan 3.
Exposure to polycyclic aromatic hydrocarbons (PAHs) during childhood has been associated with altered growth and adiposity in children. The effects of prenatal exposure to PAHs on developmental programming of growth and adiposity are still unknown.
To study the association of prenatal exposure to PAHs with early childhood growth and adiposity measures.
In NYU Children's Health and Environment Study (2016-2019), we studied 880 mother-child pairs for maternal urinary PAH metabolites in early, mid, and late pregnancy and measured child weight, length/height, triceps, and subscapular skinfold thicknesses at 1, 2, 3, and 4 years. We used linear mixed models to investigate associations between average pregnancy exposure to PAHs and the z-scores of child repeated measures. The models were adjusted for sociodemographic and health-related factors.
Children prenatally exposed to higher levels of PAHs had greater weight and length/height z scores. We found an interaction with time-point of child assessment, showing stronger associations at later ages. For instance, PAH exposure was associated with higher weight z-scores at 3 years: coefficient per Ln-unit increase in 2-NAP = 0.25 (95%CI: 0.13, 0.37), 2-PHEN = 0.25 (95%CI: 0.11, 0.39), 1-PYR = 0.13 (95%CI: 0.02, 0.24), and 4-PHEN = 0.09 (95%CI: 0.02, 0.15). Higher concentrations of 2-NAP (coefficient = 0.21, 95%CI: 0.11, 0.31), 2-PHEN (coefficient = 0.24, 95%CI: 0.12, 0.35), 3-PHEN (coefficient = 0.13, 95%CI: 0.02, 0.24]), 4-PHEN (coefficient = 0.09, 95%CI: 0.04, 0.15), and 1-PYR (coefficient = 0.11, 95%CI: 0.02, 0.21) were associated with higher weight z-score at 4 years.
Prenatal PAH exposure may contribute to the developmental programming of growth in childhood.
儿童时期接触多环芳烃（PAHs）与儿童生长发育改变及肥胖有关。产前接触PAHs对生长发育和肥胖的发育编程影响尚不清楚。
研究产前接触PAHs与儿童早期生长发育及肥胖指标之间的关联。
在纽约大学儿童健康与环境研究（2016 - 2019年）中，我们研究了880对母婴，检测孕期早、中、晚期母亲尿液中PAH代谢物，并在儿童1、2、3和4岁时测量其体重、身长/身高、三头肌和肩胛下皮褶厚度。我们使用线性混合模型研究孕期PAHs平均暴露水平与儿童重复测量z分数之间的关联。模型对社会人口统计学和健康相关因素进行了校正。
产前接触较高水平PAHs的儿童体重和身长/身高z分数更高。我们发现与儿童评估时间点存在交互作用，在较大年龄时关联更强。例如，PAH暴露与3岁时较高的体重z分数相关：2 - NAP每增加1个Ln单位的系数 = 0.25（95%置信区间：0.13，0.37），2 - PHEN = 0.25（95%置信区间：0.11，0.39），1 - PYR = 0.13（95%置信区间：0.02，0.24），4 - PHEN = 0.09（95%置信区间：0.02，0.15）。2 - NAP（系数 = 0.21，95%置信区间：0.11，0.31）、2 - PHEN（系数 = 0.24，95%置信区间：0.12，0.35）、3 - PHEN（系数 = 0.13，95%置信区间：0.02，0.24）、4 - PHEN（系数 = 0.09，95%置信区间：0.04，0.15）和1 - PYR（系数 = 0.11，95%置信区间：0.02，0.21）的较高浓度与4岁时较高的体重z分数相关。
产前PAH暴露可能有助于儿童期生长发育的编程。
