Kim Shin-Hye, Park Mi Jung, Park Sung Kyun
Department of Pediatrics, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, South Korea.
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Heliyon. 2023 Aug 22;9(9):e19335. doi: 10.1016/j.heliyon.2023.e19335. eCollection 2023 Sep.
Existing literature provides limited information on the association between childhood obesity and polycyclic aromatic hydrocarbons (PAHs), which are potentially obesogenic. We examined the association between urinary concentrations of PAH metabolites and obesity in the Korean pediatric population.
We analyzed the data of 2286 children/adolescents aged 3-17 years who participated in the Korean National Environmental Health Survey between 2015 and 2017. Urinary concentrations of 2-naphthol, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxypyrene were assayed using gas chromatography-mass spectrometry. Overweight/obesity was defined as a body mass index (BMI) for age ≥85th percentile. Multiple linear and logistic regression models were used to analyze the relationship of BMI z-score and overweight with urinary concentrations of PAH metabolites after adjusting for age, sex, household income, parental education level, physical activity, fast-food consumption, and environmental tobacco smoke exposure.
BMI z-score was positively associated with 2-naphthol concentrations in children aged 6-11 and 12-17 years and with 1-hydroxypyrene concentrations in children aged 6-11 years. In the overall population, a significant rise in odds ratios for overweight/obesity across 2-naphthol quartiles was noted. Specifically, the 3rd and 4th quartiles displayed odds ratios of 1.39 [1.03, 1.88] and 1.46 [1.08, 1.99] respectively, compared to the 1st quartile (P-for-trend = 0.006). Similar associations between 2-naphthol and overweight/obesity status were observed in the 6-11- and 12-17-year age groups. There was little evidence of an association between overweight/obesity and other PAH hydroxy derivatives.
PAH exposure may be associated with increased childhood adiposity, a potential risk factor for adult obesity and adverse metabolic outcomes.
现有文献关于儿童肥胖与多环芳烃（PAHs）之间关联的信息有限，而多环芳烃可能有致肥胖作用。我们研究了韩国儿童人群中PAH代谢物尿浓度与肥胖之间的关联。
我们分析了2015年至2017年间参与韩国国家环境卫生调查的2286名3至17岁儿童/青少年的数据。使用气相色谱 - 质谱法测定尿中2 - 萘酚、2 - 羟基芴、1 - 羟基菲和1 - 羟基芘的浓度。超重/肥胖定义为年龄别体重指数（BMI）≥第85百分位数。在调整年龄、性别、家庭收入、父母教育水平、身体活动、快餐消费和环境烟草烟雾暴露后，使用多元线性和逻辑回归模型分析BMI z评分和超重与PAH代谢物尿浓度之间的关系。
在6至11岁和12至17岁儿童中，BMI z评分与2 - 萘酚浓度呈正相关，在6至11岁儿童中与1 - 羟基芘浓度呈正相关。在总体人群中，观察到2 - 萘酚四分位数范围内超重/肥胖的比值比显著上升。具体而言，与第一四分位数相比，第三和第四四分位数的比值比分别为1.39 [1.03, 1.88]和1.46 [1.08, 1.99]（趋势P值 = 0.006）。在6至11岁和12至17岁年龄组中观察到2 - 萘酚与超重/肥胖状态之间存在类似关联。几乎没有证据表明超重/肥胖与其他PAH羟基衍生物之间存在关联。
PAH暴露可能与儿童肥胖增加有关，儿童肥胖是成人肥胖和不良代谢结局的潜在危险因素。
