Iwai Kunihisa, Norikura Toshio
Department of Applied Biology and Food Sciences, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561 Japan.
Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505 Japan.
Food Sci Biotechnol. 2024 Jul 18;34(1):277-285. doi: 10.1007/s10068-024-01657-2. eCollection 2025 Jan.
The enhanced bioavailability of quercetin (Qr), which has low absorption, may have beneficial effects on human health. This study aimed to elucidate the effects of simultaneous pectin ingestion on the absorption and antioxidant activity of Qr. Qr concentrations in the plasma and urine of rats fed Qr + cellulose or Qr + pectin diets were determined, and thiobarbituric acid reactive substances (TBARS) in oxidized low-density lipoprotein (LDL) were measured. The concentrations of Qr and its metabolites in the plasma and urine increased one day after feeding the Qr + pectin diet compared with the Qr + cellulose diet. The elevation of TBARS was suppressed in rats fed the Qr + pectin diet. Qr concentrations in the plasma and LDL increased in a dose-dependent manner with pectin. Qr levels in plasma and LDL were negatively correlated with TBARS levels in LDL. The simultaneous ingestion of pectin has been suggested to immediately enhance the absorption and antioxidant activity of Qr.
槲皮素（Qr）吸收性低，但其生物利用度的提高可能对人体健康有益。本研究旨在阐明同时摄入果胶对Qr吸收及抗氧化活性的影响。测定了喂食Qr+纤维素或Qr+果胶饮食的大鼠血浆和尿液中的Qr浓度，并测量了氧化低密度脂蛋白（LDL）中的硫代巴比妥酸反应性物质（TBARS）。与Qr+纤维素饮食相比，喂食Qr+果胶饮食一天后，大鼠血浆和尿液中Qr及其代谢物的浓度增加。喂食Qr+果胶饮食的大鼠中TBARS的升高受到抑制。血浆和LDL中的Qr浓度随果胶呈剂量依赖性增加。血浆和LDL中的Qr水平与LDL中的TBARS水平呈负相关。已表明同时摄入果胶可立即提高Qr的吸收及抗氧化活性。
