Ortiz-Peregrina Sonia, Martino Francesco, Casares-López Miriam, Granados-Delgado Pilar, Anera Rosario G, Castro Torres José J
Department of Optics, Laboratory of Vision Sciences and Applications, University of Granada, Granada, Spain.
Addiction. 2025 May;120(5):975-983. doi: 10.1111/add.16746. Epub 2025 Jan 6.
This study aimed to determine the effect of vaporized cannabidiol (CBD) on visual function and vehicle driving performance, given the growing popularity of CBD use worldwide.
Randomized, double-blind, placebo-controlled cross-over experimental study.
Laboratory of Vision Sciences and Applications, University of Granada, Spain.
Thirty participants were recruited through advertisements placed in the local newspaper and distributed among the university community. They had a mean age of 26.2 (6.2) years, and 70% were male. All of them were occasional users of CBD or cannabis, and held valid driving licenses.
Three experimental sessions, conducted one week apart, in which a placebo, 15% CBD (16 mg) or 30% CBD (32 mg) was vaporized.
The primary endpoint for driving performance was the overall driving performance score (ODPS). Secondary outcomes included visual function variables such as static and dynamic visual acuity, stereoacuity, contrast sensitivity, motion detection and other driving performance parameters such as mean speed, lateral vehicle control or reaction time.
Comparisons revealed no statistically significant changes in ODPS after vaporizing CBD at 15% or 30% compared with the placebo (χ = 0.479; P = 0.787). Visual function remained largely unchanged, with only a statistically significant decrease in motion detection (χ = 7.980; P = 0.018). Similarly, no statistically significant differences were found in driving performance secondary outcomes, such as the standard deviation of lateral lane position (χ = 0.068; P = 0.966), distance travelled outside the lane (χ = 2.530; P = 0.282), reaction time (χ = 1.000; P = 0.607), or collisions (χ = 0.987; P = 0.610). Additionally, correlations between ODPS and visual function did not yield statistically significant results.
Consumption of vaporized cannabidiol in 16 mg and 32 mg doses does not appear to affect simulated vehicle driving performance and visual function.
鉴于大麻二酚（CBD）在全球范围内的使用日益普遍，本研究旨在确定雾化CBD对视觉功能和车辆驾驶性能的影响。
随机、双盲、安慰剂对照交叉实验研究。
西班牙格拉纳达大学视觉科学与应用实验室。
通过在当地报纸上刊登广告并在大学社区内分发招募了30名参与者。他们的平均年龄为26.2（6.2）岁，70%为男性。他们均为偶尔使用CBD或大麻的用户，并持有有效驾驶执照。
相隔一周进行三次实验，分别雾化安慰剂、15% CBD（16毫克）或30% CBD（32毫克）。
驾驶性能的主要终点是总体驾驶性能评分（ODPS）。次要结果包括视觉功能变量，如静态和动态视力、立体视锐度、对比敏感度、运动检测，以及其他驾驶性能参数，如平均速度、车辆横向控制或反应时间。
比较显示，与安慰剂相比，雾化15%或30%的CBD后，ODPS没有统计学上的显著变化（χ = 0.479；P = 0.787）。视觉功能基本保持不变，仅运动检测有统计学上的显著下降（χ = 7.980；P = 0.018）。同样，在驾驶性能次要结果方面，如车道横向位置标准差（χ = 0.068；P = 0.966）、车道外行驶距离（χ = 2.530；P = 0.282）、反应时间（χ = 1.000；P = 0.607）或碰撞次数（χ = 0.987；P = 0.610），未发现统计学上的显著差异。此外，ODPS与视觉功能之间的相关性未产生统计学上的显著结果。
雾化16毫克和32毫克剂量的CBD似乎不会影响模拟车辆驾驶性能和视觉功能。
