Dayoob Mohamad, Kee Yuki Wong Yee, Bahrin Wan Hamirul, Alrimawi Bilal Harieth, Kumarasamy Vinoth, Subramaniyan Vetriselvan, Albadrani Ghadeer M, Al-Ghadi Muath Q, Kamel Mohamed, Abdel-Daim Mohamed M, Azad Abul Kalam
Faculty of Pharmacy, MAHSA University.
Radiopharmaceutical Technology Group, Medical Technology Division, Malaysia Nuclear Agency.
J Vis Exp. 2024 Dec 13(214). doi: 10.3791/67068.
A new fusidic acid-loaded hydrogel film was prepared via the solvent casting technique using alginate and Aloe vera. The hydrogel films were optimized using different ratios of sodium alginate, Aloe vera, and glycerin. The films containing 10% glycerin (w/w of alginate) exhibited the best appearance. Incorporating Aloe vera influenced the thickness, swelling behavior, water vapor permeability, and drug release profile of the hydrogel films. Higher Aloe vera content resulted in thicker films (up to a certain ratio), increased swelling, reduced water vapor permeability, and a prolonged drug release of up to 93% over 12 h. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of key functional groups and the interaction between the hydrogel components. The study suggests that the combination of sodium alginate, Aloe vera, and glycerin can improve the mechanical properties and drug release profiles of hydrogel films, making them a promising option for enhanced topical drug delivery and wound healing applications.
采用溶剂浇铸技术，以海藻酸钠和芦荟为原料制备了一种新型的负载夫西地酸的水凝胶薄膜。使用不同比例的海藻酸钠、芦荟和甘油对水凝胶薄膜进行了优化。含有10%甘油（相对于海藻酸钠的重量/重量）的薄膜外观最佳。加入芦荟会影响水凝胶薄膜的厚度、溶胀行为、水蒸气透过率和药物释放曲线。较高的芦荟含量会导致薄膜变厚（达到一定比例）、溶胀增加、水蒸气透过率降低，并且在12小时内药物释放延长至93%。傅里叶变换红外光谱（FTIR）分析证实了关键官能团的存在以及水凝胶成分之间的相互作用。该研究表明，海藻酸钠、芦荟和甘油的组合可以改善水凝胶薄膜的机械性能和药物释放曲线，使其成为增强局部药物递送和伤口愈合应用的有前景的选择。
