Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Centro Empresarial da Marinha Grande, Marinha Grande, Portugal.
Carbohydr Polym. 2013 Oct 15;98(1):311-20. doi: 10.1016/j.carbpol.2013.05.076. Epub 2013 Jun 6.
This study investigates the influence of Aloe vera on water absorption and the in vitro degradation rate of Aloe vera-Ca-alginate hydrogel films, for wound healing and drug delivery applications. The influence of A. vera content (5%, 15% and 25%, v/v) on water absorption was evaluated by the incubation of the films into a 0.1 M HCl solution (pH 1.0), acetate buffer (pH 5.5) and simulated body fluid solution (pH 7.4) during 24h. Results show that the water absorption is significantly higher for films containing high A. vera contents (15% and 25%), while no significant differences are observed between the alginate neat film and the film with 5% of A. vera. The in vitro enzymatic degradation tests indicate that an increase in the A. vera content significantly enhances the degradation rate of the films. Control films, incubated in a simulated body fluid solution without enzymes, are resistant to the hydrolytic degradation, exhibiting reduced weight loss and maintaining its structural integrity. Results also show that the water absorption and the in vitro degradation rate of the films can be tailored by changing the A. vera content.
本研究考察了芦荟对水吸收和体外降解率的影响芦荟-钙-海藻酸盐水凝胶膜，用于伤口愈合和药物输送应用。通过将薄膜浸泡在 0.1 M HCl 溶液（pH 1.0）、醋酸盐缓冲液（pH 5.5）和模拟体液溶液（pH 7.4）中 24 小时，评估了 A. vera 含量（5%、15%和 25%，v/v）对水吸收的影响。结果表明，含有高 A. vera 含量（15%和 25%）的薄膜的吸水率显著更高，而海藻酸盐纯膜与含有 5%的 A. vera 的薄膜之间没有观察到显著差异。体外酶降解试验表明，A. vera 含量的增加显著提高了薄膜的降解速率。在没有酶的模拟体液溶液中孵育的对照薄膜对水解降解具有抗性，表现出重量损失减少并保持其结构完整性。结果还表明，通过改变 A. vera 含量可以调整薄膜的吸水率和体外降解率。
