Capelusnik Dafne, Smeets Wouter, Webers Casper, Ramiro Sofia, Nikiphorou Elena, Braekers Roel, Boekel Laura, Wolbink Gertjan, Boonen Annelies
Universiteit Maastricht Care and Public Health Research Institute, Maastricht, The Netherlands.
Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
RMD Open. 2025 Jan 6;11(1):e004877. doi: 10.1136/rmdopen-2024-004877.
To establish reference intervals (RIs) for work ability, at-work productivity loss and overall productivity loss in the general working population and to compare work ability and at-work productivity loss of patients with inflammatory rheumatic and musculoskeletal disease (iRMD) with this population.
Cross-sectional analysis among patients with iRMDs and population controls without iRMDs having paid work and participating in a Dutch cohort study. They reported on three work outcomes: work ability (0-10), at-work productivity loss and overall productivity loss (0%-100%). A generalised additive model for location, shape and scale parameters was used to establish age-specific RIs and percentile curves for controls. The proportion of patients and controls below each percentile curve was compared.
413 controls were included; 73% female, with mean age 53 (SD 10) years, 60% had high education, mean work ability was 8.7 (1.6), at-work productivity loss 6.3% (7.2) and overall work productivity loss 11% (25.6).Percentile curves illustrated that work ability and at-work/overall work productivity loss were worse with increasing age. For instance, for work ability, the 95% RI for 22 to 29-year individuals was 5.9-10, while for individuals between 50 and 59 years, it was 4.9-9.1. Patients compared with controls had worse work outcomes, especially for at-work and overall productivity loss.
Work ability and productivity are not perfect in the general population, based on the newly developed RIs for the three work outcomes. This calls for caution to not overestimate the iRMD impact on work outcomes. Nevertheless, iRMD patients have worse work ability and higher work productivity loss, compared with controls.
建立一般工作人群的工作能力、工作时生产力损失和总体生产力损失的参考区间（RIs），并将炎症性风湿性和肌肉骨骼疾病（iRMD）患者的工作能力和工作时生产力损失与该人群进行比较。
对患有iRMD的患者和没有iRMD且有带薪工作并参与荷兰队列研究的人群对照进行横断面分析。他们报告了三个工作结果：工作能力（0 - 10）、工作时生产力损失和总体生产力损失（0% - 100%）。使用位置、形状和尺度参数的广义相加模型为对照建立年龄特异性的RIs和百分位数曲线。比较患者和对照在每个百分位数曲线以下的比例。
纳入了413名对照；73%为女性，平均年龄53（标准差10）岁，60%受过高等教育，平均工作能力为8.7（1.6），工作时生产力损失为6.3%（7.2），总体工作生产力损失为11%（25.6）。百分位数曲线表明，工作能力以及工作时/总体工作生产力损失随年龄增长而变差。例如，对于工作能力，22至29岁个体的95% RI为5.9 - 10，而对于50至59岁的个体，为4.9 - 9.1。与对照相比，患者的工作结果更差，尤其是在工作时和总体生产力损失方面。
根据新制定的三个工作结果的RIs，一般人群的工作能力和生产力并不理想。这提醒我们要谨慎，不要高估iRMD对工作结果的影响。然而，与对照相比，iRMD患者的工作能力更差，工作生产力损失更高。
