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傣族和汉族人群中与2型糖尿病相关的口腔微生物群差异。

Differences in oral microbiota associated with type 2 diabetes mellitus between the Dai and Han populations.

作者信息

Tang Lingtong, Ding Keke, Li Mengci, Chao Xiaowen, Sun Tao, Guo Yuhuai, Peng Xufei, Jia Wei, Chen Tianlu, Xie Guoxiang, Feng Lei

机构信息

Department of Clinical Laboratory, The People's Hospital of Gao County, Yibin, Sichuan, China.

Department of Clinical Laboratory, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, China.

出版信息

J Oral Microbiol. 2024 Dec 24;17(1):2442420. doi: 10.1080/20002297.2024.2442420. eCollection 2025.

DOI:10.1080/20002297.2024.2442420
PMID:39763576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11703080/
Abstract

BACKGROUND

Type 2 diabetes mellitus (T2DM) development is closely linked to microbiota, influenced by geography, ethnicity, gender, and age. While the relationship between oral microbiota and T2DM has been explored, specific microbiota associated with T2DM in the Dai and Han populations remains unclear. This study aims to compare oral microbiota differences and identify keystone species between these populations, both with and without T2DM.

METHODS

We recruited 28 han participants (6 healthy children, 10 healthy adults, 12 adults with T2DM) and 34 Dai participants (11 healthy children, 10 healthy adults, 13 adults with T2DM). Blood samples were collected for biochemical analysis, and saliva samples underwent DNA extraction and 16S rRNA sequencing.

RESULTS

Age significantly influenced oral microbiota differences between the Dai and Han populations, overshadowing the effects of diabetes. In the Dai population with T2DM, notable increases in , ., , and were observed compared to the Han population. Keystone genera differed, with central to the Dai population's microbial network, while the Han network was more scattered.

CONCLUSION

This is the first comparative analysis of oral microbiota in the Dai and Han populations with T2DM, highlighting age and ethnicity's influence on microbial composition.

摘要

背景

2型糖尿病（T2DM）的发生与微生物群密切相关，受地理、种族、性别和年龄影响。虽然口腔微生物群与T2DM之间的关系已被探讨，但傣族和汉族人群中与T2DM相关的特定微生物群仍不清楚。本研究旨在比较这两个人群（有和没有T2DM）的口腔微生物群差异，并确定关键物种。

方法

我们招募了28名汉族参与者（6名健康儿童、10名健康成年人、12名患有T2DM的成年人）和34名傣族参与者（11名健康儿童、10名健康成年人、13名患有T2DM的成年人）。采集血样进行生化分析，唾液样本进行DNA提取和16S rRNA测序。

结果

年龄对傣族和汉族人群的口腔微生物群差异有显著影响，超过了糖尿病的影响。在患有T2DM的傣族人群中，与汉族人群相比，观察到[具体物种]、[具体物种]、[具体物种]和[具体物种]显著增加。关键属不同，[具体属]是傣族人群微生物网络的核心，而汉族网络更为分散。

结论

这是首次对患有T2DM的傣族和汉族人群的口腔微生物群进行比较分析，突出了年龄和种族对微生物组成的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/fae5af80019c/ZJOM_A_2442420_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/8b28ec54217f/ZJOM_A_2442420_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/4066189266a7/ZJOM_A_2442420_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/70141f6f799b/ZJOM_A_2442420_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/3bd28d57bada/ZJOM_A_2442420_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/fae5af80019c/ZJOM_A_2442420_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/8b28ec54217f/ZJOM_A_2442420_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/4066189266a7/ZJOM_A_2442420_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/70141f6f799b/ZJOM_A_2442420_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/3bd28d57bada/ZJOM_A_2442420_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e70/11703080/fae5af80019c/ZJOM_A_2442420_F0005_OC.jpg

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本文引用的文献

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Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations.傣族与汉族人群2型糖尿病相关肠道微生物群的比较研究。
World J Diabetes. 2023 Dec 15;14(12):1766-1783. doi: 10.4239/wjd.v14.i12.1766.
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Identifying keystone species in microbial communities using deep learning.使用深度学习识别微生物群落中的关键种。
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Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.
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Front Endocrinol (Lausanne). 2023 Oct 5;14:1256292. doi: 10.3389/fendo.2023.1256292. eCollection 2023.
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