Wang Chunyan, Sun Chao, Ding Ziyan, Wu Xiujuan, Liu Kangding, Cao Jie
Department of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Department of Orthopedic Surgery, Orthopedic Center, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Int J Nanomedicine. 2024 Dec 31;19:14171-14191. doi: 10.2147/IJN.S493987. eCollection 2024.
The recovery process following ischemic stroke is a complex undertaking involving intricate cellular and molecular interactions. Cellular dysfunction or aberrant pathways can lead to complications such as brain edema, hemorrhagic transformation, and glial scar hyperplasia, hindering angiogenesis and nerve regeneration. These abnormalities may contribute to long-term disability post-stroke, imposing significant burdens on both families and society. Current clinical interventions primarily focus on endovascular therapy, overlooking the protection of brain cells themselves. However, the use of bioactive materials in stroke management has shown notable safety and efficacy. By precisely targeting the ischemic site at a cellular and molecular level, this therapeutic approach mitigates ischemia-induced brain tissue damage and promotes site repair. This review examines the protective benefits of bioactive materials in reducing cell damage and facilitating nerve restoration in accordance with the pathophysiological basis of ischemic stroke. Enhanced understanding of ischemic stroke mechanisms has the potential to advance the targeted and efficient clinical use of bioactive materials.
缺血性中风后的恢复过程是一项复杂的任务，涉及复杂的细胞和分子相互作用。细胞功能障碍或异常途径可导致脑水肿、出血转化和胶质瘢痕增生等并发症，阻碍血管生成和神经再生。这些异常可能导致中风后长期残疾，给家庭和社会带来巨大负担。目前的临床干预主要集中在血管内治疗，而忽视了对脑细胞本身的保护。然而，生物活性材料在中风治疗中的应用已显示出显著的安全性和有效性。通过在细胞和分子水平上精确靶向缺血部位，这种治疗方法减轻了缺血性脑组织损伤并促进了损伤部位的修复。本文根据缺血性中风的病理生理基础，综述了生物活性材料在减少细胞损伤和促进神经恢复方面的保护作用。对缺血性中风机制的深入理解有可能推动生物活性材料在临床中的靶向高效应用。
