Guru Santosh, Lam Fred C, Akhavan-Sigari Amirhossein, Hori Yusuke S, AbuReesh Deyaaldeen, Tayag Armine, Emrich Sara C, Ustrzynski Louisa, Park David J, Chang Steven D
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Brain Sci. 2024 Dec 13;14(12):1253. doi: 10.3390/brainsci14121253.
The current standard of care for brain tumor management includes maximal safe surgical resection followed by concurrent chemotherapy and radiation therapy. Recent advances in image-guided surgical techniques have enhanced the precision of tumor resections, yet there remains a critical need for innovative technologies to further improve patient outcomes. Techniques such as fluorescence image-guided neurosurgery in combination with stereotactic radiosurgery have improved outcomes for patients with brain tumors. In this article for Brain Science's Special Issue , we review the use of image-guided neurosurgery and stereotactic radiosurgery for the treatment of brain tumors. In addition, we summarize the emerging use of theranostic nanoparticles for the delivery of diagnostic and therapeutic technologies to enable the neurosurgeon to perform more precise surgical resections in the operating room, to specifically target the delivery of existing and novel treatments to tumor cells, and to augment the efficacy of stereotactic radiosurgery. These innovative translational tools will allow neurosurgeons, neuro-oncologists, and radiation oncologists to go "beyond the knife" to improve the survival of brain tumor patients.
目前脑肿瘤治疗的标准护理包括最大限度的安全手术切除，随后进行同步化疗和放射治疗。图像引导手术技术的最新进展提高了肿瘤切除的精度，但仍迫切需要创新技术来进一步改善患者预后。荧光图像引导神经外科手术与立体定向放射外科手术等技术改善了脑肿瘤患者的预后。在本文的《脑科学》特刊中，我们回顾了图像引导神经外科手术和立体定向放射外科手术在脑肿瘤治疗中的应用。此外，我们总结了治疗诊断纳米颗粒在递送诊断和治疗技术方面的新兴应用，以使神经外科医生能够在手术室进行更精确的手术切除，将现有和新型治疗方法特异性地靶向递送至肿瘤细胞，并增强立体定向放射外科手术的疗效。这些创新的转化工具将使神经外科医生、神经肿瘤学家和放射肿瘤学家能够“超越手术刀”，提高脑肿瘤患者的生存率。
