Fox H E, Moessinger A C
Am J Obstet Gynecol. 1985 Feb 15;151(4):531-3. doi: 10.1016/0002-9378(85)90283-2.
Hypoplasia of the fetal lung is found in association with long-standing oligohydramnios. In animal models, interference with fetal breathing activity has led to lung hypoplasia. It has been suggested that lung hypoplasia associated with oligohydramnios is due to inhibition of fetal breathing. Observations of seven patients with prolonged oligohydramnios, three of whom had lung hypoplasia, indicate that fetal breathing does occur in these cases and that is unlikely that lung hypoplasia is merely the result of absent fetal breathing activity. In fact, when compared to the four patients with oligohydramnios and presumably normal lungs, the three patients with oligohydramnios and lung hypoplasia spent more time breathing and did so at higher rates.
胎儿肺发育不全与长期羊水过少有关。在动物模型中，干扰胎儿呼吸活动会导致肺发育不全。有人提出，与羊水过少相关的肺发育不全是由于胎儿呼吸受到抑制。对7例羊水过少持续时间较长的患者进行观察，其中3例有肺发育不全，结果表明这些病例中确实存在胎儿呼吸，而且肺发育不全不太可能仅仅是胎儿呼吸活动缺失的结果。事实上，与4例羊水过少且推测肺部正常的患者相比，3例羊水过少且有肺发育不全的患者呼吸时间更长，呼吸频率也更高。
