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有伴侣动物和无伴侣动物人群的肠道微生物群比较分析。

Comparative Analysis of Gut Microbiota in Humans Living with and Without Companion Animals.

作者信息

Do Kyung-Hyo, Park Jiwon, Kim Nahee, Ryu Dahye, Kim Min-Gyu, Ahn Hyunjung, Kim Hakhyun, Hwang Jun-Gi, Park Min-Kyu, Seo Kwang-Won, Lee Wan-Kyu

机构信息

College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.

GutBiomeTech Co., Ltd., Cheongju 28644, Republic of Korea.

出版信息

Life (Basel). 2024 Dec 6;14(12):1621. doi: 10.3390/life14121621.

DOI:10.3390/life14121621
PMID:39768329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11678384/
Abstract

Cohabitation with companion animals (CAs) has been suggested as a significant modifier of gut microbial diversity. This study investigated the influence of cohabitation with CAs on human gut microbiota composition. Using 16S rRNA gene sequencing, we analyzed the gut microbiota of 20 families with CAs (40 adults, 20 children) and 20 families without CAs (40 adults, 20 children). Alpha and beta diversity analyses were performed, and the differentially abundant genera were identified. There were significant differences in beta diversity across the groups (-value = 0.001). The / ratio was considerably lower in the CAs group (0.67) than in the without-CAs group (1.02). _UCG-003 (log2 fold change: 7.3; adjusted -value ≤ 0.001), (log2 fold change: 6.3; adjusted -value ≤ 0.001), and (log2 fold change: 5.1; adjusted -value = 0.012) were elevated in the group cohabiting with CAs, whereas (with CAs: 3.81%; without CAs: 13.52%) and (with CAs: 3.77%; without CAs: 6.50%) were more prevalent in the group without CAs. Cohabitation with CAs may positively influence the gut microbiota by promoting the presence of beneficial bacteria and reducing the / ratio. This study highlights the potential for cohabitation with CAs to promote gut microbial health.

摘要

与伴侣动物(CA)同居被认为是肠道微生物多样性的一个重要调节因素。本研究调查了与CA同居对人类肠道微生物群组成的影响。我们使用16S rRNA基因测序分析了20个有CA的家庭(40名成年人,20名儿童)和20个没有CA的家庭(40名成年人,20名儿童)的肠道微生物群。进行了α和β多样性分析,并确定了差异丰富的属。各组之间的β多样性存在显著差异(P值 = 0.001)。CA组的F/B比率(0.67)明显低于无CA组(1.02)。在与CA同居的组中,UCG - 003(log2倍变化:7.3;校正P值≤0.001)、Ruminococcus(log2倍变化:6.3;校正P值≤0.001)和Blautia(log2倍变化:5.1;校正P值 = 0.012)升高,而Prevotella(有CA组:3.81%;无CA组:13.52%)和Streptococcus(有CA组:3.77%;无CA组:6.50%)在无CA组中更为普遍。与CA同居可能通过促进有益细菌的存在和降低F/B比率对肠道微生物群产生积极影响。本研究强调了与CA同居促进肠道微生物健康的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/371c3966b234/life-14-01621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/ed772e26358a/life-14-01621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/10afbdfdc0a6/life-14-01621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/78da25ae5c68/life-14-01621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/54aa2a459699/life-14-01621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/e2f04f67d77a/life-14-01621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/070e4562ff82/life-14-01621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/371c3966b234/life-14-01621-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/ed772e26358a/life-14-01621-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/10afbdfdc0a6/life-14-01621-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/78da25ae5c68/life-14-01621-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/54aa2a459699/life-14-01621-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/e2f04f67d77a/life-14-01621-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/070e4562ff82/life-14-01621-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/11678384/371c3966b234/life-14-01621-g007.jpg

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Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with -displaying recombinant SARS-CoV-2 spike epitopes in mice.
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Selenobaculum gbiensis gen. nov. sp. nov., a new bacterium isolated from the gut microbiota of a patient with Crohn's disease.硒杆状菌属 gbiensis 种,是从克罗恩病患者肠道微生物群中分离到的一种新细菌。
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