Yun Somi, Seo Yongsuk, Lee Yunbin, Lee Dae Taek
Exercise Physiology Laboratory, Kookmin University, Seoul, Republic of Korea.
J Exerc Sci Fit. 2024 Oct;22(4):375-382. doi: 10.1016/j.jesf.2024.07.003. Epub 2024 Jul 25.
The purpose of this study is to investigate changes in gut microbiota related to metabolic diseases after moderate and high-intensity exercise. A total of 24 participants were divided into three groups: Non-Exercise Group (NEG, n = 8, 28.6 ± 5.3 years, 176.0 ± 7.8 cm, 81.3 ± 14.6 kg), Moderate Intensity Exercise Group (MIEG, n = 8, 26.5 ± 3.3 years, 176.9 ± 5.0 cm, 75.4 ± 9.5 kg), and Vigorous Intensity Exercise Group (VIEG, n = 8, 30.6 ± 5.9 years, 174.2 ± 3.5 cm, 77.8 ± 12.2 kg).
The participants were selected by assessing physical activity, gut health status, presence of diseases, recent disease diagnoses, and dietary disorders. Those who reported any presence disease or recent disease diagnosis were excluded from the current study. Stool samples were collected after a 10-h fast for gut microbiome analysis. MIEG participants trained at 40-59 % heart rate reserve (HRR) for at least 150 min per week, while VIEG participants trained at ≥ 60 % HRR for at least 90 min per week. After 4 weeks, all participants provided stool samples for gut microbiome analysis.Data analysis was conducted using the Wilcoxon test, with statistical significance set at ≤ 0.05.
The results indicated an increase in Prevotella in MIEG, while Veillonella, Dorea_formicigenerans, and Dorea_longicatena exhibited a decrease (p < 0.05). In VIEG, there was an increase in Bacteroides, Butyricimonas, Odoribacter, and Alistipes (p < 0.05).
These modified microbial groups were associated with factors related to metabolic diseases, including inflammatory bowel disease, obesity, colorectal cancer, diabetes, hypertension, metabolic liver diseases, and ischemic heart diseases. Additional research is essential to delve into the relationship between exercise and these alterations in the microbiome.
本研究旨在调查中高强度运动后肠道微生物群与代谢性疾病相关的变化。共有24名参与者被分为三组：非运动组（NEG，n = 8，28.6±5.3岁，176.0±7.8厘米，81.3±14.6千克）、中等强度运动组（MIEG，n = 8，26.5±3.3岁，176.9±5.0厘米，75.4±9.5千克）和高强度运动组（VIEG，n = 8，30.6±5.9岁，174.2±3.5厘米，77.8±12.2千克）。
通过评估身体活动、肠道健康状况、疾病存在情况、近期疾病诊断和饮食失调来选择参与者。报告有任何疾病或近期疾病诊断的人被排除在本研究之外。禁食10小时后收集粪便样本进行肠道微生物组分析。MIEG组参与者以心率储备（HRR）的40 - 59%进行训练，每周至少150分钟，而VIEG组参与者以≥60% HRR进行训练，每周至少90分钟。4周后，所有参与者提供粪便样本进行肠道微生物组分析。使用Wilcoxon检验进行数据分析，统计学显著性设定为≤0.05。
结果表明，MIEG组中普雷沃氏菌增加，而韦荣氏菌、甲酸生成多雷氏菌和长链多雷氏菌减少（p < 0.05）。在VIEG组中，拟杆菌、丁酸单胞菌、气味杆菌和阿里斯杆菌增加（p < 0.05）。
这些微生物群的改变与代谢性疾病相关因素有关，包括炎症性肠病、肥胖、结直肠癌、糖尿病、高血压、代谢性肝病和缺血性心脏病。进一步研究深入探讨运动与微生物组这些变化之间的关系至关重要。
