Mancaş Violeta, Mincă Dana Galieta, Trifu Simona Corina
Department of Complementary Sciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;
Rom J Morphol Embryol. 2025 Jan-Mar;66(1):69-79. doi: 10.47162/RJME.66.1.06.
Schizophrenia is a complex and debilitating neuropsychiatric syndrome. Although research into the etiology of this pathology has advanced considerably, consistent results are still awaited. The discovery of biomarkers that could underlie diagnosis and treatment could revolutionize the management of this pathology, and approaching biomarkers from an evolutionary perspective, along with the multitude of existing and future studies, can provide important information. The complexity of this multifactorial pathology requires its approach from an integrated and multidisciplinary perspective, which considers research on neurodevelopment, genetics, imaging and, last but not least, neurobiological research. The present material aims to bring to light a series of recent research, as well as the approach to this pathology from an evolutionary perspective of neurodevelopment, in the hope that it will constitute an attractive point of view that could imagine new ways of approaching this pathology.
精神分裂症是一种复杂且使人衰弱的神经精神综合征。尽管对这种病症病因的研究已经取得了相当大的进展，但仍在等待一致的结果。能够作为诊断和治疗基础的生物标志物的发现可能会彻底改变这种病症的管理方式，从进化的角度研究生物标志物，连同现有的和未来的大量研究，能够提供重要信息。这种多因素病症的复杂性需要从综合和多学科的角度来研究，这包括对神经发育、遗传学、影像学的研究，以及最后但同样重要的神经生物学研究。本材料旨在揭示一系列近期研究，以及从神经发育的进化角度对这种病症的研究方法，希望它能构成一个有吸引力的观点，从而设想出处理这种病症的新方法。
