Vogt Antonia, Faher Anissa, Kucharczak Joanna, Birch Mark, McCaskie Andrew, Khan Wasim
Division of Trauma & Orthopaedic Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
School of Clinical Medicine, University of Cambridge, Cambridge CB2 2SP, UK.
Int J Mol Sci. 2024 Dec 19;25(24):13585. doi: 10.3390/ijms252413585.
Mesenchymal stromal cells (MSCs) have the potential for novel treatments of several musculoskeletal conditions due to their ability to differentiate into several cell lineages including chondrocytes, adipocytes and osteocytes. Researchers are exploring whether this could be utilized for novel therapies for joint afflictions. The role of gender in the ability of MSCs to differentiate and proliferate into different cells has not been clearly defined. This systematic review aims to report the current literature on studies, characterized by high quality and in-depth analysis even though quantitatively limited, that have looked at the role of gender in the differentiation and proliferation of MSCs. Sixteen studies were identified during the literature search, reporting 533 patients, of which 202 were male and 331 were female. MSC proliferation, phenotypic analysis and differentiation are reported and contrasted in terms of donor gender. Heterogeneity in methodologies across studies likely contributes to the inconclusive findings presented here, with no discernible statistical disparity observed between genders in differentiation traits. Nevertheless, the proliferation results indicate a notable gender-related impact. Future investigations should aim to ascertain the potential influence of gender on MSC proliferation capacities more conclusively, emphasizing the necessity of standardized protocols for MSC analyses to enhance accuracy and comparability across studies.
间充质基质细胞（MSCs）具有分化为多种细胞谱系（包括软骨细胞、脂肪细胞和骨细胞）的能力，因此有潜力用于多种肌肉骨骼疾病的新型治疗。研究人员正在探索这是否可用于关节疾病的新型疗法。性别在MSCs分化和增殖为不同细胞的能力方面所起的作用尚未明确界定。本系统综述旨在报告当前关于性别在MSCs分化和增殖中作用的高质量且深入分析（尽管数量有限）研究的文献。在文献检索过程中确定了16项研究，报告了533名患者，其中202名是男性，331名是女性。根据供体性别报告并对比了MSCs的增殖、表型分析和分化情况。各研究方法的异质性可能导致了此处呈现的不确定结果，在分化特征方面未观察到性别之间明显的统计学差异。然而，增殖结果表明存在显著的性别相关影响。未来的研究应旨在更确凿地确定性别对MSCs增殖能力的潜在影响，强调MSCs分析标准化方案的必要性，以提高研究间的准确性和可比性。
