Cui Weiwei, Hao Meng, Yang Xin, Yin Chengqian, Chu Bo
Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan 250012, China.
Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518107, China.
Trends Cell Biol. 2025 Apr;35(4):341-351. doi: 10.1016/j.tcb.2024.08.006. Epub 2024 Sep 10.
Ferroptosis is programmed cell death induced by iron-driven lipid peroxidation. Numerous studies have shown that ferroptosis is implicated in the progression of colorectal cancer (CRC) and has emerged as a promising strategy to combat therapy-resistant CRC. While the intrinsic antiferroptotic and proferroptotic pathways in CRC cells have been well characterized, extrinsic metabolism pathways regulating ferroptosis in CRC pathogenesis remain less understood. Emerging evidence shows that gut microbial metabolism is tightly correlated with the progression of CRC. This review provides an overview of gut microbial metabolism and discusses how these metabolites derived from intestinal microflora contribute to cancer plasticity through ferroptosis. Targeting gut microbe-mediated ferroptosis is a potential approach for CRC treatment.
铁死亡是由铁驱动的脂质过氧化诱导的程序性细胞死亡。大量研究表明，铁死亡与结直肠癌（CRC）的进展有关，并已成为对抗治疗耐药性CRC的一种有前景的策略。虽然CRC细胞中的内在抗铁死亡和促铁死亡途径已得到充分表征，但在CRC发病机制中调节铁死亡的外在代谢途径仍了解较少。新出现的证据表明，肠道微生物代谢与CRC的进展密切相关。本综述概述了肠道微生物代谢，并讨论了这些源自肠道微生物群的代谢产物如何通过铁死亡促进癌症可塑性。靶向肠道微生物介导的铁死亡是CRC治疗的一种潜在方法。
