Janiczek-Polewska Marlena, Kolenda Tomasz, Poter Paulina, Jagiełło Inga, Kozłowska-Masłoń Joanna, Regulska Katarzyna, Malicki Julian, Marszałek Andrzej
Department of Clinical Oncology, Greater Poland Cancer Center, 61-866 Poznan, Poland.
Department of Electroradiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Int J Mol Sci. 2024 Dec 20;25(24):13632. doi: 10.3390/ijms252413632.
Malignant tumors are a leading cause of death worldwide, second only to cardiovascular disease. They occur in every population and have a high risk of mortality. The etiopathogenesis of malignant tumors is diverse and there are still many unknowns, leading to huge diagnostic and therapeutic challenges. Therefore, the search for ideal diagnostic and therapeutic agents is ongoing. One of the promising factors affecting cancer is the nucleus accumbens associated protein 1 (NACC1). It is a transcriptional coregulator. Moreover, it plays a multifaceted role in promoting tumorigenesis. NACC1 expression analyses were performed using The Cancer Genome Atlas (TCGA) data accessed from the University of Alabama at Birmingham Cancer (UALCAN) database, and the expression data were interconnected with clinicopathological parameters. All statistical analyses were conducted using GraphPad Prism and Statistica. The results revealed that NACC1 was expressed in almost all of the analyzed cancers, and its expression level correlates with different clinicopathological parameters. This study demonstrates that NACC1 is potentially involved in the pathogenesis, invasion, and immune response associated with many cancers. However, NACC1 is not a suitable candidate as a diagnostic biomarker as it is not specific for any type of malignancy and there are discrepancies in its expression in relation to many clinicopathological parameters. The implementation of NACC1 as a therapeutic target may improve the effectiveness of cancer treatments.
恶性肿瘤是全球主要死因之一，仅次于心血管疾病。它们在各人群中均有发生，且死亡率很高。恶性肿瘤的病因发病机制多种多样，仍有许多未知之处，这导致了巨大的诊断和治疗挑战。因此，寻找理想的诊断和治疗药物的工作仍在继续。影响癌症的一个有前景的因素是伏隔核相关蛋白1（NACC1）。它是一种转录共调节因子。此外，它在促进肿瘤发生方面发挥着多方面的作用。使用从阿拉巴马大学伯明翰分校癌症（UALCAN）数据库获取的癌症基因组图谱（TCGA）数据进行了NACC1表达分析，并将表达数据与临床病理参数相互关联。所有统计分析均使用GraphPad Prism和Statistica进行。结果显示，NACC1在几乎所有分析的癌症中均有表达，其表达水平与不同的临床病理参数相关。本研究表明，NACC1可能参与了许多癌症的发病机制、侵袭和免疫反应。然而，NACC1并非合适的诊断生物标志物候选物，因为它对任何类型的恶性肿瘤都不具有特异性，且其表达在许多临床病理参数方面存在差异。将NACC1作为治疗靶点可能会提高癌症治疗的有效性。
