钙镁改性碳氧化硅基非晶陶瓷的微观结构与生物活性
Microstructure and Bioactivity of Ca- and Mg-Modified Silicon Oxycarbide-Based Amorphous Ceramics.
作者信息
Liu Qidong, Chen Hongmei, Wu Xiumei, Yan Junjie, Yang Biaobiao, Shi Chenying, Li Yunping, Yu Shu
机构信息
National Key Laboratory of Science and Technology on High-Strength Structural Materials, Central South University, Changsha 410083, China.
School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China.
出版信息
Materials (Basel). 2024 Dec 17;17(24):6159. doi: 10.3390/ma17246159.
Silicon oxycarbide (SiOC), Ca- and Mg-modified silicon oxycarbide (SiCaOC and SiMgOC) were synthesized via sol-gel processing with subsequent pyrolysis in an inert gas atmosphere. The physicochemical structures of the materials were characterized by XRD, SEM, FTIR, and Si MAS NMR. Biocompatibility and in vitro bioactivity were detected by MTT, cell adhesion assay, and simulated body fluid (SBF) immersion test. Mg and Ca were successfully doped into the network structure of SiOC, and the non-bridging oxygens (NBO) were formed. The hydroxycarbonate apatite (HCA) was formed on the modified SiOC surface after soaking in simulated body fluid (SBF) for 14 days, and the HCA generation rate of SiCaOC was higher than that of SiMgOC. Accompanying the increase of bioactivity, the network connectivity (NC) of the modified SiOC decreased from 6.05 of SiOC to 5.80 of SiCaOC and 5.60 of SiMgOC. However, structural characterization and biological experiments revealed the nonlinear relationship between the biological activity and NC of the modified SiOC materials.
通过溶胶 - 凝胶法制备了碳氧化硅（SiOC）、钙镁改性碳氧化硅（SiCaOC和SiMgOC），随后在惰性气体气氛中进行热解。采用X射线衍射（XRD）、扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）和硅固体核磁共振（Si MAS NMR）对材料的物理化学结构进行了表征。通过MTT法、细胞黏附试验和模拟体液（SBF）浸泡试验检测了材料的生物相容性和体外生物活性。镁和钙成功掺杂到SiOC的网络结构中，并形成了非桥氧（NBO）。在模拟体液（SBF）中浸泡14天后，改性SiOC表面形成了羟基碳酸磷灰石（HCA），且SiCaOC的HCA生成速率高于SiMgOC。随着生物活性的提高，改性SiOC的网络连通性（NC）从SiOC的6.05降至SiCaOC的5.80和SiMgOC的5.60。然而，结构表征和生物学实验揭示了改性SiOC材料的生物活性与NC之间的非线性关系。
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