Suwiński Grzegorz, Nowak Izabela
Department of Applied Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Research and Developement Department, Przedsiębiorstwo Farmaceutyczne Farmapol Sp. z o. o, Święty Wojciech 29, 61-749 Poznań, Poland.
Pharmaceuticals (Basel). 2024 Dec 18;17(12):1709. doi: 10.3390/ph17121709.
Honey is widely recognized for its potential benefits in skincare, yet its incorporation into formulations is challenging due to its stickiness. This study aimed to evaluate the effects of hand creams with varying concentrations of multifloral honey (0%, 5%, 10%, and 15% /) on skin parameters and to assess their application characteristics.
A total of 24 volunteers were divided into two groups, each receiving a blinded pair of creams (0%/10% or 5%/15% honey) to apply on their left and right hands. Instrumental methods (Corneometer, Tewameter, Cutometer, Visioscan, and Visioline) were used to measure skin parameters at the baseline, 15 min after the first application, and after 4 weeks of regular use. Sensory characteristics were evaluated through participant questionnaires.
After 4 weeks, honey-infused creams showed notable improvements in skin moisturization (up to 29.7%), smoothness (up to 21.3%), wrinkle area reduction (up to 21.4%), and mean wrinkle depth reduction (up to 11.7%). Among these, the increases in moisturization and reductions in wrinkle depth were statistically significant compared to the placebo. The sensory evaluations revealed no significant differences between formulations, highlighting the vehicle's effectiveness in minimizing the stickiness typically associated with honey.
This study highlights the efficacy of honey-enriched hand creams in enhancing skin parameters over time while maintaining favorable sensory characteristics. These findings support the use of honey in dermatological formulations and provide insights into overcoming its formulation challenges.
蜂蜜因其在护肤方面的潜在益处而被广泛认可，然而由于其粘性，将其纳入配方具有挑战性。本研究旨在评估不同浓度（0%、5%、10%和15%）的多花蜂蜜护手霜对皮肤参数的影响，并评估其应用特性。
总共24名志愿者被分为两组，每组收到一对未标明成分的护手霜（0%/10%或5%/15%蜂蜜），分别涂抹在左手和右手上。使用仪器方法（角质层水合测定仪、经皮水分流失测定仪、皮肤弹性测定仪、皮肤表面图像分析仪和皮肤光泽度测定仪）在基线、首次涂抹后15分钟以及连续使用4周后测量皮肤参数。通过参与者问卷评估感官特性。
4周后，添加蜂蜜的护手霜在皮肤保湿（高达29.7%）、光滑度（高达21.3%）、皱纹面积减少（高达21.4%）和平均皱纹深度减少（高达11.7%）方面显示出显著改善。其中，与安慰剂相比，保湿增加和皱纹深度减少具有统计学意义。感官评估显示不同配方之间没有显著差异，突出了载体在最大程度减少通常与蜂蜜相关的粘性方面的有效性。
本研究强调了富含蜂蜜的护手霜随着时间推移在改善皮肤参数同时保持良好感官特性方面的功效。这些发现支持在皮肤科配方中使用蜂蜜，并为克服其配方挑战提供了见解。
