自身免疫性疾病中常见的IgA和IgM类风湿因子独特型
Common IgA and IgM rheumatoid factor idiotypes in autoimmune diseases.
作者信息
Gharavi A E, Patel B M, Hughes G R, Elkon K B
出版信息
Ann Rheum Dis. 1985 Mar;44(3):155-8. doi: 10.1136/ard.44.3.155.
Anti-idiotypic antibodies to four monoclonal IgM, one polyclonal IgM, and one polyclonal IgA rheumatoid factors were produced in rabbits and tested for cross reactivity with rheumatoid factors from nine patients with essential mixed cryoglobulinaemia, three patients with rheumatoid arthritis, four patients with systemic sicca syndrome, and one patient with systemic lupus erythematosus. Variable (3/16 to 10/16) cross reactivity for each anti-idiotypic antibody was observed which was not restricted by disease category, clonality, or isotype of the rheumatoid factor. These findings suggest that rheumatoid factor genes are highly conserved from the germ-line antibody repertoire.
针对四种单克隆IgM、一种多克隆IgM和一种多克隆IgA类风湿因子的抗独特型抗体在兔体内产生，并检测其与来自9例原发性混合性冷球蛋白血症患者、3例类风湿关节炎患者、4例系统性干燥综合征患者和1例系统性红斑狼疮患者的类风湿因子的交叉反应性。观察到每种抗独特型抗体的交叉反应性各不相同（3/16至10/16），且不受类风湿因子的疾病类别、克隆性或同种型限制。这些发现表明，类风湿因子基因在种系抗体库中高度保守。
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