II型原发性混合性冷球蛋白血症中类风湿因子和免疫球蛋白的自发产生及商陆有丝分裂原诱导产生
Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia.
作者信息
Sinico R A, Fiorini G, Fornasieri A, Bernasconi P, Benuzzi S, Paracchini M L, D'Amico G
出版信息
Ann Rheum Dis. 1986 Jul;45(7):591-5. doi: 10.1136/ard.45.7.591.
In order to evaluate functional lymphocyte defects in type II essential mixed cryoglobulinaemia (EMC) in vitro production of immunoglobulins (Ig) and rheumatoid factor (RF) has been studied in basal conditions and under pokeweed mitogen (PWM) stimulation in 15 patients and in 17 control subjects. The major finding was a significantly high basal and inducible production of RF by EMC lymphocytes as compared with the RF production in controls, while synthesis of polyclonal Ig was unaffected. A good correlation existed between in vitro production and serum levels of RF. Peripheral blood SmIg+ and Ia+ cells were also significantly increased. The possibility that EMC shares some pathogenetic mechanism with rheumatoid arthritis on the one hand and with lymphoproliferative diseases on the other is considered.
为了评估II型原发性混合性冷球蛋白血症（EMC）中的功能性淋巴细胞缺陷，对15例患者和17例对照者在基础条件下以及在商陆有丝分裂原（PWM）刺激下的免疫球蛋白（Ig）和类风湿因子（RF）的体外产生情况进行了研究。主要发现是，与对照组的RF产生相比，EMC淋巴细胞的基础RF产生和诱导性RF产生显著升高，而多克隆Ig的合成未受影响。体外产生与血清RF水平之间存在良好的相关性。外周血SmIg +和Ia +细胞也显著增加。一方面考虑了EMC与类风湿性关节炎、另一方面与淋巴增殖性疾病共享某些致病机制的可能性。
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