II型原发性混合性冷球蛋白血症中类风湿因子和免疫球蛋白的自发产生及商陆有丝分裂原诱导产生

Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia.

作者信息

Sinico R A, Fiorini G, Fornasieri A, Bernasconi P, Benuzzi S, Paracchini M L, D'Amico G

出版信息

Ann Rheum Dis. 1986 Jul;45(7):591-5. doi: 10.1136/ard.45.7.591.

DOI:10.1136/ard.45.7.591

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001942/

Abstract

In order to evaluate functional lymphocyte defects in type II essential mixed cryoglobulinaemia (EMC) in vitro production of immunoglobulins (Ig) and rheumatoid factor (RF) has been studied in basal conditions and under pokeweed mitogen (PWM) stimulation in 15 patients and in 17 control subjects. The major finding was a significantly high basal and inducible production of RF by EMC lymphocytes as compared with the RF production in controls, while synthesis of polyclonal Ig was unaffected. A good correlation existed between in vitro production and serum levels of RF. Peripheral blood SmIg+ and Ia+ cells were also significantly increased. The possibility that EMC shares some pathogenetic mechanism with rheumatoid arthritis on the one hand and with lymphoproliferative diseases on the other is considered.

摘要

为了评估II型原发性混合性冷球蛋白血症（EMC）中的功能性淋巴细胞缺陷，对15例患者和17例对照者在基础条件下以及在商陆有丝分裂原（PWM）刺激下的免疫球蛋白（Ig）和类风湿因子（RF）的体外产生情况进行了研究。主要发现是，与对照组的RF产生相比，EMC淋巴细胞的基础RF产生和诱导性RF产生显著升高，而多克隆Ig的合成未受影响。体外产生与血清RF水平之间存在良好的相关性。外周血SmIg +和Ia +细胞也显著增加。一方面考虑了EMC与类风湿性关节炎、另一方面与淋巴增殖性疾病共享某些致病机制的可能性。

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Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia.II型原发性混合性冷球蛋白血症中类风湿因子和免疫球蛋白的自发产生及商陆有丝分裂原诱导产生

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引用本文的文献

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The kidney in mixed cryoglobulinemias.混合性冷球蛋白血症中的肾脏。

Springer Semin Immunopathol. 1987;9(4):395-415. doi: 10.1007/BF00197217.

本文引用的文献

1

Physiology and pathology of rheumatoid factors.类风湿因子的生理学与病理学

Springer Semin Immunopathol. 1981;4(2):161-79. doi: 10.1007/BF01857093.

2

Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients.混合性冷球蛋白血症：40例患者的临床情况及长期随访

Am J Med. 1980 Aug;69(2):287-308. doi: 10.1016/0002-9343(80)90390-3.

3

Cellular localization of rheumatoid factor idiotypes.类风湿因子独特型的细胞定位。

J Clin Invest. 1982 Jun;69(6):1356-65. doi: 10.1172/jci110575.

4

Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis.商陆有丝分裂原诱导自身抗体产生在类风湿关节炎中的细胞需求

J Immunol. 1980 Sep;125(3):1125-9.

5

In vitro immunoglobulin production by peripheral blood mononuclear cells from multiple myeloma patients and patients with benign monoclonal gammopathy. Regulation by cell subsets.多发性骨髓瘤患者和良性单克隆丙种球蛋白病患者外周血单个核细胞的体外免疫球蛋白产生。细胞亚群的调节作用。

Scand J Immunol. 1984 Feb;19(2):149-57. doi: 10.1111/j.1365-3083.1984.tb00911.x.

6

Secondary and essential cryoglobulinemias. Frequency, nosological classification, and long-term follow-up.

Acta Haematol. 1983;70(2):73-82. doi: 10.1159/000206699.

7

Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production.

Clin Immunol Immunopathol. 1983 Apr;27(1):96-109. doi: 10.1016/0090-1229(83)90059-4.

8

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