干燥综合征（原发性干燥综合征）中的自身抗体。
Autoantibodies in the sicca syndrome (primary Sjögren's syndrome).
作者信息
Elkon K B, Gharavi A E, Hughes G R, Moutsoupoulos H M
出版信息
Ann Rheum Dis. 1984 Apr;43(2):243-5. doi: 10.1136/ard.43.2.243.
Abstract
IgA and IgM rheumatoid factors as well as antibodies to Ro and La were measured in 37 patients with the sicca syndrome and 9 patients with Sjögren's syndrome secondary to rheumatoid arthritis. Positive results were found in 84% (IgA rheumatoid factor), 76% (IgM rheumatoid factor), 62% (Ro), and 50% (La) of patients with the sicca syndrome. There was no significant difference in the frequency of positive results in patients with glandular versus extraglandular disease. Antibodies to La invariably occurred in patients with antibodies to Ro. In addition, patients who were anti-Ro positive also had significantly higher IgA (p less than 0.05) and IgM (p less than 0.01) rheumatoid factor activity. Since 81% of the sicca patients were concordant for 3 of the 4 antibodies tested, production of these autoantibodies appears to be related.
摘要
对37例干燥综合征患者和9例类风湿关节炎继发干燥综合征患者检测了IgA和IgM类风湿因子以及抗Ro和抗La抗体。干燥综合征患者中，84%（IgA类风湿因子）、76%（IgM类风湿因子）、62%（Ro）和50%（La）检测结果呈阳性。腺体疾病患者与腺外疾病患者检测结果阳性频率无显著差异。抗La抗体总是出现在抗Ro抗体阳性的患者中。此外，抗Ro阳性的患者IgA（p<0.05）和IgM（p<0.01）类风湿因子活性也显著更高。由于81%的干燥综合征患者4种检测抗体中的3种检测结果一致，这些自身抗体的产生似乎有关联。
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