Karatepe Yahya Kaan, Kesici Ugur, Duman Mehmet Güray, Genç Mahmut Salih, Bozali Kubra, Guler Eray Metin, Sade Ayşe Gökçen, Oba Sibel
Department of General Surgery, Malatya Battalgazi State Hospital, Malatya-Türkiye.
Department of General Surgery, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul-Türkiye.
Ulus Travma Acil Cerrahi Derg. 2025 Jan;31(1):1-8. doi: 10.14744/tjtes.2024.44676.
Intraabdominal adhesions increase the incidence and length of surgical complications. Many anti-adhesive agents have been used for this purpose, but no definitive solution has yet been found. Studies on the prevention and reduction of anastomotic leakage, therefore, remain up to date. This study aimed to determine the effects of Rosmarinus Officinalis extract on colon anastomosis as a surgical model, its antiadhesive activity, and its impact on wound healing in the laparotomy site simultaneously to facilitate the clinical application of Rosmarinus Officinalis extract.
The rats were divided into two groups of seven rats each. Group C (Control): Laparotomy with colon anastomosis + 2 mL isotonic solution. Group R (Rosmarinus officinalis): Laparotomy + colon anastomosis, + 2 mL of 2% rosmarinus officinalis. Macroscopic adhesion scoring was performed and recorded. The tensile strength of the wound was assessed using tissue samples obtained from the incision line. From the incision line, tissue samples were obtained for histopathological investigation and tissue hydroxyproline levels. Anastomotic burst pressure was measured from the segment of colon anastomosis.
In terms of Macroscopic adhesion score, there was no statistically significant difference between Group C and Group R (p=1.000). The mean Wound tensile strength value of Group R was significantly lower than that of Group C (p=0.003). In terms of mean Anastomotic burst pressure, there was no statistically significant difference between Group C and Group R (p=0.078).
According to the findings of our investigation, peritoneal administration of Rosmarinus Officinalis extract in the early postoperative period may increase the risk of evisceration in the abdominal incision site.
腹腔粘连会增加手术并发症的发生率和持续时间。许多抗粘连剂已被用于此目的，但尚未找到确切的解决方案。因此，关于预防和减少吻合口漏的研究仍然是最新的。本研究旨在确定迷迭香叶提取物作为手术模型对结肠吻合术的影响、其抗粘连活性以及对剖腹手术切口部位伤口愈合的影响，以促进迷迭香叶提取物的临床应用。
将大鼠分为两组，每组七只。C组（对照组）：进行结肠吻合术的剖腹手术 + 2 mL等渗溶液。R组（迷迭香叶组）：剖腹手术 + 结肠吻合术， + 2 mL 2%迷迭香叶提取物。进行宏观粘连评分并记录。使用从切口线获取的组织样本评估伤口的抗张强度。从切口线获取组织样本进行组织病理学检查和组织羟脯氨酸水平检测。从结肠吻合段测量吻合口破裂压力。
在宏观粘连评分方面，C组和R组之间无统计学显著差异（p = 1.000）。R组的平均伤口抗张强度值显著低于C组（p = 0.003）。在平均吻合口破裂压力方面，C组和R组之间无统计学显著差异（p = 0.078）。
根据我们的研究结果，术后早期腹腔内给予迷迭香叶提取物可能会增加腹部切口部位脏器脱出的风险。
