胸膜间皮瘤的治疗：美国临床肿瘤学会指南更新

Treatment of Pleural Mesothelioma: ASCO Guideline Update.

作者信息

Kindler Hedy L, Ismaila Nofisat, Bazhenova Lyudmila, Chu Quincy, Churpek Jane E, Dagogo-Jack Ibiayi, Bryan Darren S, Drazer Michael W, Forde Patrick, Husain Aliya N, Sauter Jennifer L, Rusch Valerie, Bradbury Penelope A, Cho B C John, de Perrot Marc, Ghafoor Azam, Graham David L, Khorshid Ola, Lebensohn Alexandra, White Julie, Hassan Raffit

机构信息

University of Chicago Medicine, Chicago, IL.

American Society of Clinical Oncology, Alexandria, VA.

出版信息

J Clin Oncol. 2025 Mar 10;43(8):1006-1038. doi: 10.1200/JCO-24-02425. Epub 2025 Jan 8.

DOI:10.1200/JCO-24-02425

PMID:39778125

Abstract

PURPOSE

To provide evidence-based recommendations to practicing physicians and others on the management of pleural mesothelioma (PM).

METHODS

ASCO convened an Expert Panel of medical oncology, thoracic surgery, radiation oncology, pathology, cancer genetics, and advocacy experts to conduct an updated literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2016 through 2024. Outcomes of interest included survival, disease-free or recurrence-free survival, and quality of life. Expert Panel members used available evidence and informal consensus to develop evidence-based guideline recommendations.

RESULTS

The literature search identified 110 additional relevant studies to inform the evidence base for this guideline.

RECOMMENDATIONS

Evidence-based recommendations were developed for surgical cytoreduction, immunotherapy, chemotherapy, pathology, and germline testing in patients with PM.Additional information is available at www.asco.org/thoracic-cancer-guidelines.

摘要

目的

为执业医师及其他人员提供关于胸膜间皮瘤（PM）管理的循证建议。

方法

美国临床肿瘤学会召集了一个由医学肿瘤学、胸外科、放射肿瘤学、病理学、癌症遗传学及宣传专家组成的专家小组，进行最新文献检索，其中包括2016年至2024年发表的系统评价、荟萃分析、随机对照试验以及前瞻性和回顾性比较观察性研究。感兴趣的结果包括生存率、无病或无复发生存率以及生活质量。专家小组成员利用现有证据和非正式共识制定循证指南建议。