Ouyang Chuang, Huang Jiaying, Huang Gonghua, Wang Yanyan
Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, School of Medical Technology, Guangdong Medical University. Dongguan, Guangdong 523808, China.
Int J Med Sci. 2025 Jan 1;22(2):417-431. doi: 10.7150/ijms.105532. eCollection 2025.
Allergic diseases are a group of chronic inflammatory disorders driven by abnormal immune responses. Dendritic cells (DCs) play a pivotal role in the initiation and progression of allergic diseases by modulating T cell responses. Extensive progress has been made in characterizing crucial roles of metabolic reprogramming in the regulation of immune cell functions. As the critical upstream regulators and effectors in allergic responses, the activation, migration, and function of DCs are reliant on metabolic reprogramming. In this review, we summarize the metabolic characteristics of DCs, and how the cellular microenvironment shapes DC function. We also elucidate the metabolic regulation of DC biology in the context of allergic diseases and targeted therapeutic strategies based on DC metabolism regulation. Understanding the functional alterations in DCs during allergic responses and the underlying mechanisms governing its metabolic regulation is crucial for the development of effective strategies for the prevention and treatment of allergic diseases.
过敏性疾病是一组由异常免疫反应驱动的慢性炎症性疾病。树突状细胞（DCs）通过调节T细胞反应在过敏性疾病的发生和发展中起关键作用。在表征代谢重编程在免疫细胞功能调节中的关键作用方面已经取得了广泛进展。作为过敏反应中的关键上游调节因子和效应器，DCs的激活、迁移和功能依赖于代谢重编程。在这篇综述中，我们总结了DCs的代谢特征，以及细胞微环境如何塑造DC功能。我们还阐明了在过敏性疾病背景下DC生物学的代谢调节以及基于DC代谢调节的靶向治疗策略。了解过敏反应期间DCs的功能改变及其代谢调节的潜在机制对于制定预防和治疗过敏性疾病的有效策略至关重要。
