Britton Emily M, Taisir Radia, Cooper Alysha, Li Yao, Sousa Sarah, Chorny Yelena, MacKillop James, Costello Mary Jean
Homewood Research Institute.
Homewood Health Centre.
Cannabis. 2024 Dec 12;7(3):74-89. doi: 10.26828/cannabis/2024/000260. eCollection 2024.
The present research evaluated the impact of legalizing recreational cannabis among individuals with substance use disorders (SUDs) who may already use cannabis at high rates.
Using an interrupted time series study design, we evaluated the potential impact of legalizing recreational cannabis among individuals seeking treatment for SUD within a hospital-based treatment setting in Guelph, Ontario. We examined 2,925 individuals who entered an inpatient SUD treatment program between April 2017 and December 2021. We performed segmented regression analyses using both the date of cannabis legalization and the date of edibles legalization as the interruption time point. We also performed stratified analyses to examine potential sex differences.
We found no significant changes in the frequency of cannabis use using either of the interruption time points. However, among the subsample who had used cannabis, there was evidence of increasing CUD severity post-legalization of edibles, as well as an overall decreasing trend in readiness to quit over time. Stratified analyses also suggested possible sex differences in frequency of cannabis use, CUD severity, and readiness to quit.
Results point to some small but potentially important impacts of recreational cannabis legalization that may only continue with time. Nevertheless, there is a need to continue to monitor cannabis use trends over time to understand any potential lagged effects.
本研究评估了娱乐用大麻合法化对可能已大量使用大麻的物质使用障碍(SUD)个体的影响。
采用中断时间序列研究设计,我们评估了安大略省圭尔夫市一家医院治疗机构中,娱乐用大麻合法化对寻求SUD治疗的个体的潜在影响。我们研究了2925名在2017年4月至2021年12月期间进入住院SUD治疗项目的个体。我们以大麻合法化日期和食用大麻制品合法化日期作为中断时间点进行了分段回归分析。我们还进行了分层分析以检验潜在的性别差异。
我们发现,使用任何一个中断时间点,大麻使用频率均无显著变化。然而,在曾使用过大麻的子样本中,有证据表明食用大麻制品合法化后大麻使用障碍(CUD)严重程度增加,以及随着时间推移戒烟意愿总体呈下降趋势。分层分析还表明,在大麻使用频率、CUD严重程度和戒烟意愿方面可能存在性别差异。
结果表明娱乐用大麻合法化有一些虽小但可能重要的影响,且可能会随时间持续存在。尽管如此,仍有必要持续监测大麻使用趋势,以了解任何潜在的滞后效应。