Ghio R, Haupt E, Pistoia V, Perata A, Minale P, Ratti M, Boccaccio P
Blut. 1985 Mar;50(3):135-40. doi: 10.1007/BF00320069.
Using an in vitro method that allows the study of the colony forming capacity of phytohemagglutinin stimulated peripheral blood T lymphocytes, we have detected an impaired T cell colony formation in hemodialyzed renal failure patients. By contrast a near normal pattern of responses was observed in patients treated with a conservative therapy. The poor in vitro T cell responsiveness of hemodialyzed patients was not corrected by supplementing the cultures with an adherent cell contitioned medium prepared from normal donors. We conclude that an intrinsic defect of the T cell colony forming capacity exists in hemodialyzed patients.
使用一种体外方法来研究植物血凝素刺激的外周血T淋巴细胞的集落形成能力，我们检测到血液透析的肾衰竭患者中T细胞集落形成受损。相比之下，接受保守治疗的患者观察到接近正常的反应模式。用从正常供体制备的贴壁细胞条件培养基补充培养物，并未纠正血液透析患者体外T细胞反应性差的情况。我们得出结论，血液透析患者存在T细胞集落形成能力的内在缺陷。
