Quattrochi J J, McBride P T, Yates A J
Brain Res. 1985 Jan 28;325(1-2):39-48. doi: 10.1016/0006-8993(85)90300-2.
Quantitative analysis of reticular dendritic spines was performed on rapid Golgi impregnated neurons in 7 brainstem areas from 61 sudden infant death syndrome (SIDS) and 34 control infants. Throughout the first postnatal year, mean spine density in SIDS was significantly greater than the mean density in controls (P less than 0.0001). There were significantly higher values of spine density in SIDS compared to controls (P less than 0.0001) in both term and preterm infants. Within the SIDS brainstem itself, the density of dendritic spines was significantly different (P less than 0.05) between two medullary regions and between reticular and non-reticular formation areas. Among these brainstem areas in controls, there was no significant difference. Our findings indicate an immature developmental pattern of increased dendritic spine density in the SIDS brainstem which may be responsible for abnormal central respiratory and arousal control. These significant quantitative differences in spine density are considered in the present study to represent an anatomical substrate of brainstem immaturity in the multifactorial pathogenesis of SIDS.
对61例婴儿猝死综合征（SIDS）和34例对照婴儿的7个脑干区域中经快速高尔基浸染法处理的神经元进行了网状树突棘的定量分析。在出生后的第一年，SIDS组的平均棘密度显著高于对照组（P<0.0001）。足月儿和早产儿中，SIDS组的棘密度值均显著高于对照组（P<0.0001）。在SIDS的脑干内部，两个延髓区域之间以及网状结构和非网状结构区域之间的树突棘密度存在显著差异（P<0.05）。在对照组的这些脑干区域中，没有显著差异。我们的研究结果表明，SIDS脑干中树突棘密度增加的发育模式不成熟，这可能是导致中枢呼吸和觉醒控制异常的原因。本研究认为，这些棘密度的显著定量差异代表了SIDS多因素发病机制中脑干不成熟的解剖学基础。
