Lei Shizhen, Liu Yani
Department of Ophthalmology, Wuhan No.1 Hospital, Wuhan, Hubei, China.
Department of Otolaryngology & Head and Neck Surgery, Wuhan No.1 Hospital, Wuhan, Hubei, China.
Transl Vis Sci Technol. 2025 Jan 2;14(1):5. doi: 10.1167/tvst.14.1.5.
Previous researches have suggested an important association between gut microbiota (GM) and vascular pathologies such as atherosclerosis. This study aimed to explore the association between 196 GM taxa and retinal vein occlusion (RVO).
This study used Mendelian randomization (MR), linkage disequilibrium score regression (LDSC), and polygenic overlap analysis. Genome-wide association study (GWAS) data associated with 196 GM taxa was obtained from the MiBioGen consortium, involving a large number of European-ancestry participants. GWAS data of RVO was obtained from the FinnGen consortium and another study that also involved European-ancestry participants. Inverse-variance weighted was used as the primary approach for MR estimation. Moreover, LDSC and polygenic overlap analyses were performed to evaluate the genetic correlation between GM taxa and RVO.
The MR results identified the association of six GM taxa, including class Bacilli, order Lactobacillales, family Streptococcaceae, genus Clostridium innocuum group, genus Family XIII AD3011 group, and genus Subdoligranulum with the development of RVO. In addition, the polygenic overlap analysis supported the genetic association between GM and RVO.
Our findings confirmed the association between six GM taxa and the development of RVO, thereby highlighting the effects of GM on retinal vascular health.
The results may provide the rationale for developing GM-based strategies for preventing the onset of RVO.
先前的研究表明肠道微生物群（GM）与动脉粥样硬化等血管病变之间存在重要关联。本研究旨在探讨196种GM分类群与视网膜静脉阻塞（RVO）之间的关联。
本研究采用孟德尔随机化（MR）、连锁不平衡评分回归（LDSC）和多基因重叠分析。与196种GM分类群相关的全基因组关联研究（GWAS）数据来自MiBioGen联盟，涉及大量欧洲血统参与者。RVO的GWAS数据来自FinnGen联盟和另一项同样涉及欧洲血统参与者的研究。逆方差加权法用作MR估计的主要方法。此外，还进行了LDSC和多基因重叠分析，以评估GM分类群与RVO之间的遗传相关性。
MR结果确定了六种GM分类群与RVO发生之间的关联，包括芽孢杆菌纲、乳杆菌目、链球菌科、无害梭菌属组、XIII AD3011科属组和Subdoligranulum属。此外，多基因重叠分析支持了GM与RVO之间的遗传关联。
我们的研究结果证实了六种GM分类群与RVO发生之间的关联，从而突出了GM对视网膜血管健康的影响。
这些结果可能为制定基于GM的预防RVO发病策略提供理论依据。
