Carman George M, Stukey Geordan J, Jog Ruta, Han Gil-Soo
Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ, 08901, USA.
Department of Food Science and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ, 08901, USA.
Adv Biol Regul. 2025 Jan;95:101074. doi: 10.1016/j.jbior.2025.101074. Epub 2025 Jan 3.
Phosphatidic acid phosphatase, a conserved eukaryotic enzyme that catalyzes the Mg-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol, has emerged as a vital regulator of lipid homeostasis. By controlling the balance of phosphatidic acid and diacylglycerol, the enzyme governs the use of the lipids for synthesis of the storage lipid triacylglycerol and the membrane phospholipids needed for cell growth. The mutational, biochemical, and cellular analyses of yeast phosphatidic acid phosphatase have provided insights into the structural determinants of enzyme function with the understanding of its regulation by phosphorylation and dephosphorylation. The key role that the enzyme plays in triacylglycerol synthesis indicates it may be a potential drug target to ameliorate obesity in humans. The enzyme activity, which is critical to the growth and virulence of pathogenic fungi, is a proposed target for therapeutic development to ameliorate fungal infections.
磷脂酸磷酸酶是一种保守的真核酶，催化磷脂酸的镁依赖性去磷酸化反应生成二酰基甘油，已成为脂质稳态的重要调节因子。通过控制磷脂酸和二酰基甘油的平衡，该酶调控脂质用于合成储存脂质三酰基甘油以及细胞生长所需的膜磷脂。对酵母磷脂酸磷酸酶的突变、生化和细胞分析，有助于深入了解酶功能的结构决定因素以及对其磷酸化和去磷酸化调节的认识。该酶在三酰基甘油合成中发挥的关键作用表明，它可能是改善人类肥胖的潜在药物靶点。这种对致病真菌的生长和毒力至关重要的酶活性，是开发治疗真菌感染的潜在靶点。
