1型糖尿病儿童和青少年与无糖尿病的病例对照同龄人相比的睡眠健康综合指标和昼夜节律类型。
The sleep health composite and chronotype among children and adolescents with type 1 diabetes compared to case-control peers without diabetes.
作者信息
İpar Necla, Boran Perran, Barış Hatice Ezgi, Us Mahmut Caner, Aygün Burcu, Haliloğlu Belma, Baygül Arzu, Mutlu Gül Yeşiltepe, Bereket Abdullah, Hatun Şükrü
机构信息
Institute of Health Sciences, Social Pediatrics PhD Program, Marmara University, Istanbul, Turkey.
Department of Pediatrics, Koc University School of Medicine, Istanbul, Turkey.
出版信息
J Clin Sleep Med. 2025 May 1;21(5):825-834. doi: 10.5664/jcsm.11558.
STUDY OBJECTIVES
Our objectives were to compare sleep health composite dimensions and chronotype in children and adolescents with and without type 1 diabetes (T1D) and to explore the relationship between sleep and glycemic variability in T1D.
METHODS
The study comprised 84 participants with T1D aged between 6 to 18 years and age- and sex-matched controls. The sleep health composite was measured using actigraphy, sleep diaries, and self or parental reports. Sleep disturbance was evaluated using the DSM-5 Level 2 Sleep Disorders Scale Short Form. Chronotype was determined using the Children's Chronotype Questionnaire.
RESULTS
The median total sleep health composite score for both the T1D and control groups was 3.0 (3.0-4.0) ( = .485). Sleep quality was reported as good by 89.3% of participants with T1D and 96.4% of controls ( = .072). Objective data from actigraphy indicated poor sleep quality in 56% of participants with T1D and 59.5% of controls ( = .639). Additionally, 88% of participants with T1D and 84.5% of controls had inadequate total age-appropriate sleep duration ( = .501). Among participants with T1D, those with a stable glycemic variability (coefficient of variation < 36%) had an earlier midpoint sleep ( = .008).
CONCLUSIONS
Our study indicates that there are no significant differences in the sleep health composite and chronotype between children and adolescents with and without T1D. Although most participants reported good sleep quality, objective assessments indicated poor sleep quality. These findings suggest that children and adolescents may overestimate their sleep quality.
CLINICAL TRIAL REGISTRATION
Registry: ClinicalTrials.gov; Name: Sleep Patterns and Chronotype in Children With and Without Type 1 Diabetes; URL: https://clinicaltrials.gov/study/NCT06318611; Identifier: NCT06318611.
CITATION
İpar N, Boran P, Barış HE, et al. The sleep health composite and chronotype among children and adolescents with type 1 diabetes compared to case-control peers without diabetes. 2025;21(5):825-834.
研究目的
我们的目的是比较1型糖尿病（T1D）患儿和青少年与非T1D患儿和青少年的睡眠健康综合维度和昼夜节律类型，并探讨T1D患儿睡眠与血糖变异性之间的关系。
方法
该研究纳入了84名年龄在6至18岁之间的T1D患儿以及年龄和性别匹配的对照组。使用活动记录仪、睡眠日记以及自我或家长报告来测量睡眠健康综合指标。使用DSM-5二级睡眠障碍量表简表评估睡眠障碍。使用儿童昼夜节律问卷确定昼夜节律类型。
结果
T1D组和对照组的睡眠健康综合总分中位数均为3.0（3.0 - 4.0）（P = 0.485）。89.3%的T1D患儿和96.4%的对照组患儿报告睡眠质量良好（P = 0.072）。活动记录仪的客观数据显示，56%的T1D患儿和59.5%的对照组患儿睡眠质量较差（P = 0.639）。此外，88%的T1D患儿和84.5%的对照组患儿的总睡眠时间未达到与其年龄相适应的充足时长（P = 0.501）。在T1D患儿中，血糖变异性稳定（变异系数< 36%）的患儿睡眠中点时间更早（P = 0.008）。
结论
我们的研究表明，患有和未患有T1D的儿童和青少年在睡眠健康综合指标和昼夜节律类型方面没有显著差异。尽管大多数参与者报告睡眠质量良好，但客观评估显示睡眠质量较差。这些发现表明儿童和青少年可能高估了他们的睡眠质量。
临床试验注册
注册机构：ClinicalTrials.gov；名称：1型糖尿病患儿与非糖尿病患儿的睡眠模式和昼夜节律类型；网址：https://clinicaltrials.gov/study/NCT06318611；标识符：NCT06318611。
引用文献
İpar N, Boran P, Barış HE,等。1型糖尿病患儿和青少年与无糖尿病的病例对照同龄人相比的睡眠健康综合指标和昼夜节律类型。2025；21(5):825 - 834。
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