Miyake Kentaro, Yoshida Satomi, Takeuchi Masato, Kawakami Koji
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
Ann Thorac Surg Short Rep. 2024 May 24;2(3):590-595. doi: 10.1016/j.atssr.2024.04.029. eCollection 2024 Sep.
Suitable tracheostomy timing after cardiac operation remains controversial; hence, this study compared the effectiveness of early and late tracheostomy after cardiac operation.
By using the nationwide administrative claims database in Japan, patients who underwent cardiac operation between April 2010 and March 2020 were identified and included in this study. In-hospital mortality, incidence of deep sternal wound infection, and ventilator-free days were analyzed and compared by dividing patients into 2 groups: an early group (patients who underwent tracheostomy 1-14 days postoperatively) and a late group (patients who underwent tracheostomy 15-30 days postoperatively). Baseline characteristics were adjusted by propensity score weighting.
Of 1240 patients who underwent cardiac operation and postoperative tracheostomy, 784 were included in the main analysis cohort. As the number of days between the operation and tracheostomy increased, in-hospital mortality increased, whereas ventilator-free days decreased. The early and late groups comprised 284 and 326 patients, respectively. After adjustment of baseline characteristics, the in-hospital mortality (odds ratio, 0.65; 95% CI, 0.46-0.91; = .01) was lower in the early group than in the late group, the incidence of deep sternal wound infection (odds ratio, 0.59; 95% CI, 0.23-1.52; = .27) was not significantly different between the 2 groups, and the early group had more ventilator-free days compared with the late group (mean difference, 5.1; 95% CI, 3.6-6.5; < .001).
Early tracheostomy may be considered in patients expected to require prolonged ventilation.
心脏手术后合适的气管切开时机仍存在争议;因此,本研究比较了心脏手术后早期和晚期气管切开的效果。
通过使用日本全国性行政索赔数据库,确定并纳入了2010年4月至2020年3月期间接受心脏手术的患者。将患者分为两组进行分析和比较:早期组(术后1 - 14天接受气管切开的患者)和晚期组(术后15 - 30天接受气管切开的患者),分析比较住院死亡率、深部胸骨伤口感染发生率和无呼吸机天数。通过倾向评分加权调整基线特征。
在1240例接受心脏手术和术后气管切开的患者中,784例被纳入主要分析队列。随着手术与气管切开之间天数的增加,住院死亡率增加,而无呼吸机天数减少。早期组和晚期组分别包括284例和326例患者。调整基线特征后,早期组的住院死亡率低于晚期组(比值比,0.65;95%可信区间,0.46 - 0.91;P = 0.01),两组深部胸骨伤口感染发生率无显著差异(比值比,0.59;95%可信区间,0.23 - 1.52;P = 0.27),与晚期组相比,早期组的无呼吸机天数更多(平均差值,5.1;95%可信区间,3.6 - 6.5;P < 0.001)。
对于预计需要长时间通气的患者,可考虑早期气管切开。