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JC病毒感染神经胶质细胞的诊断见解：与多瘤病毒微小病毒核体相关的点状包涵体的术中细胞病理学分析

Diagnostic Insighhts Into JC Virus-Infected Glial Cells: Intraoperative Cytopathological Analysis of Dot-Shaped Inclusions Associated With PML-NBs.

作者信息

Ujihira Nobuko, Doi Hideki, Shishido-Hara Yukiko

机构信息

Department of Diagnostic Pathology, Hekinan Municipal Hospital, Hekinan, Japan.

Department of Neurology, Hekinan Municipal Hospital, Hekinan, Japan.

出版信息

Cytopathology. 2025 May;36(3):281-284. doi: 10.1111/cyt.13469. Epub 2025 Jan 10.

DOI:10.1111/cyt.13469
PMID:39791275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982780/
Abstract

This is the first case report describing the diagnostic value of dot-shaped inclusions associated with promyelocytic leukaemia nuclear bodies (PML-NBs) to define JC virus-infected glial cells in an intraoperative cytopathological diagnosis for progressive multifocal leukoencephalopathy (PML).

摘要

这是首例描述点状包涵体与早幼粒细胞白血病核体（PML-NBs）相关联在进行性多灶性白质脑病（PML）术中细胞病理学诊断中用于定义JC病毒感染神经胶质细胞的诊断价值的病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407d/11982780/c3d41a735f8d/CYT-36-281-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407d/11982780/2001ec1cf716/CYT-36-281-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407d/11982780/c3d41a735f8d/CYT-36-281-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407d/11982780/2001ec1cf716/CYT-36-281-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/407d/11982780/c3d41a735f8d/CYT-36-281-g001.jpg

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本文引用的文献

1
The Nucleolus and Its Interactions with Viral Proteins Required for Successful Infection.核仁及其与病毒蛋白的相互作用对成功感染至关重要。
Cells. 2024 Sep 21;13(18):1591. doi: 10.3390/cells13181591.
2
The interactions between PML nuclear bodies and small and medium size DNA viruses.PML 核体与小中型 DNA 病毒之间的相互作用。
Virol J. 2023 May 1;20(1):82. doi: 10.1186/s12985-023-02049-4.
3
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease.进行性多灶性白质脑病与 JC 病毒相关疾病谱。
Nat Rev Neurol. 2021 Jan;17(1):37-51. doi: 10.1038/s41582-020-00427-y. Epub 2020 Nov 20.
4
Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned.进行性多灶性白质脑病的发病机制和多发性硬化症治疗相关的风险：十年来的经验教训。
Lancet Neurol. 2018 May;17(5):467-480. doi: 10.1016/S1474-4422(18)30040-1.
5
Natalizumab-associated PML: Challenges with incidence, resulting risk, and risk stratification.那他珠单抗相关的进行性多灶性白质脑病：发病率、所致风险及风险分层方面的挑战
Neurology. 2017 Mar 21;88(12):1197-1205. doi: 10.1212/WNL.0000000000003739. Epub 2017 Feb 22.
6
JC virus inclusions in progressive multifocal leukoencephalopathy: scaffolding promyelocytic leukemia nuclear bodies grow with cell cycle transition through an S-to-G2-like state in enlarging oligodendrocyte nuclei.多灶性进行性白质脑病中 JC 病毒包涵体：支架性早幼粒细胞白血病核体通过在增大的少突胶质细胞核中类似于 S 到 G2 期的状态，随着细胞周期的转变而生长。
J Neuropathol Exp Neurol. 2014 May;73(5):442-53. doi: 10.1097/NEN.0000000000000066.
7
JC virus intranuclear inclusions associated with PML-NBs: analysis by electron microscopy and structured illumination microscopy.JC 病毒核内包含体与 PML-NBs 的关系：电子显微镜和结构光照明显微镜分析。
Am J Pathol. 2012 Mar;180(3):1095-1106. doi: 10.1016/j.ajpath.2011.11.036. Epub 2012 Jan 21.
8
Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease.进行性多灶性白质脑病和早幼粒细胞白血病核小体：JC 病毒诱导脱髓鞘疾病的临床、神经病理学和病毒学方面的综述。
Acta Neuropathol. 2010 Sep;120(3):403-17. doi: 10.1007/s00401-010-0694-x. Epub 2010 May 13.
9
PML nuclear bodies.多系统萎缩小体神经元包涵体。
Cold Spring Harb Perspect Biol. 2010 May;2(5):a000661. doi: 10.1101/cshperspect.a000661. Epub 2010 Apr 21.
10
Major and minor capsid proteins of human polyomavirus JC cooperatively accumulate to nuclear domain 10 for assembly into virions.人类多瘤病毒JC的主要和次要衣壳蛋白协同聚集到核结构域10，以组装成病毒颗粒。
J Virol. 2004 Sep;78(18):9890-903. doi: 10.1128/JVI.78.18.9890-9903.2004.