通过代谢重编程心肌细胞表观基因组来再生心脏。
Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome.
机构信息
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; National Health Commission Key Laboratory of Chronobiology, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China; Development and Related Diseases of Women and Children, Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, No.17 People's South Road, Chengdu, Sichuan 610041, China.
出版信息
Cell Metab. 2023 Nov 7;35(11):1849-1851. doi: 10.1016/j.cmet.2023.10.007.
In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates cardiomyocyte cell-cycle reentry and heart regeneration in adult animals.
在哺乳动物青春期，心肌细胞迅速退出细胞周期，而成年后心脏损伤后的再生能力有限。最近，Li 等人在《自然》杂志上的研究表明，抑制脂肪酸氧化可以重新连接细胞代谢，并导致心肌细胞的表观遗传重编程为不成熟状态，从而促进成年动物心肌细胞的细胞周期再进入和心脏再生。
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