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使用inovivo系统在癌症小鼠模型中应用肿瘤治疗电场的方案。

Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system.

作者信息

Gates Travis J, Zbidat Sewar, Deniz Karina, Padmanabhan Sanyukta, Ladner Katherine, Sarkari Akshat, Zhao Xianda, Davidi Shiri, Blatt Roni, Cahal Shay, Gabay Martin, Sellevoll Mariell, Tzchori Itai, Porat Yaara, Haber Adi, Giladi Moshe, Subramanian Subbaya, Lou Emil

机构信息

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA.

Novocure Ltd., Haifa, Israel.

出版信息

STAR Protoc. 2025 Mar 21;6(1):103535. doi: 10.1016/j.xpro.2024.103535. Epub 2025 Jan 9.

DOI:10.1016/j.xpro.2024.103535
PMID:39792561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11780090/
Abstract

Tumor Treating Fields (TTFields) are electric fields clinically approved for cancer treatment, delivered via arrays attached to the patient's skin. Here, we present a protocol for applying TTFields to torso orthotopic and subcutaneous mouse tumor models using the inovivo system. We guide users on proper system component connections, study protocol design, mouse fur depilation, array application, and treatment condition adjustment and monitoring. The inovivo system allows for the concurrent application of TTFields with standard cancer therapies. For complete details on the use and execution of this protocol, please refer to Barsheshet et al..

摘要

肿瘤治疗电场（TTFields）是临床上已获批准用于癌症治疗的电场，通过附着在患者皮肤上的阵列进行传递。在此，我们展示了一种使用inovivo系统将TTFields应用于躯干原位和皮下小鼠肿瘤模型的方案。我们指导用户进行系统组件的正确连接、研究方案设计、小鼠脱毛、阵列应用以及治疗条件的调整和监测。inovivo系统允许将TTFields与标准癌症疗法同时应用。有关本方案使用和执行的完整详细信息，请参考巴谢谢特等人的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4ecf27aa618a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/f76c334b505e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/f19592166d47/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/e0980e8a9659/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/25add80297be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4de4c2c2b823/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/df1f80e05ee9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/8333b4c5bef4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4e1c29bb58fa/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4ecf27aa618a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/f76c334b505e/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/f19592166d47/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/e0980e8a9659/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/25add80297be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4de4c2c2b823/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/df1f80e05ee9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/8333b4c5bef4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4e1c29bb58fa/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca73/11780090/4ecf27aa618a/gr8.jpg

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1
Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system.使用inovivo系统在癌症小鼠模型中应用肿瘤治疗电场的方案。
STAR Protoc. 2025 Mar 21;6(1):103535. doi: 10.1016/j.xpro.2024.103535. Epub 2025 Jan 9.
2
The dielectric properties of skin and their influence on the delivery of tumor treating fields to the torso: a study combining in vivo measurements with numerical simulations.皮肤的介电特性及其对肿瘤治疗电场传递到躯干的影响：结合体内测量和数值模拟的研究。
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本文引用的文献

1
Association of Tumor Treating Fields (TTFields) therapy with survival in newly diagnosed glioblastoma: a systematic review and meta-analysis.肿瘤治疗电场（TTFields）治疗与新诊断胶质母细胞瘤患者生存的关联：系统评价和荟萃分析。
J Neurooncol. 2023 Aug;164(1):1-9. doi: 10.1007/s11060-023-04348-w. Epub 2023 Jul 26.
2
Tumor Treating Fields (TTFields) Concomitant with Immune Checkpoint Inhibitors Are Therapeutically Effective in Non-Small Cell Lung Cancer (NSCLC) In Vivo Model.肿瘤治疗电场（TTFields）联合免疫检查点抑制剂在非小细胞肺癌（NSCLC）体内模型中具有治疗效果。
Int J Mol Sci. 2022 Nov 15;23(22):14073. doi: 10.3390/ijms232214073.
3
The Mechanisms of Action of Tumor Treating Fields.
肿瘤治疗电场的作用机制。
Cancer Res. 2022 Oct 17;82(20):3650-3658. doi: 10.1158/0008-5472.CAN-22-0887.
4
Tumor Treating Fields (TTFields) downregulate the Fanconi Anemia-BRCA pathway and increase the efficacy of chemotherapy in malignant pleural mesothelioma preclinical models.肿瘤电场治疗（TTFields）下调范可尼贫血-BRCA 通路，并增加恶性胸膜间皮瘤临床前模型中化疗的疗效。
Lung Cancer. 2021 Oct;160:99-110. doi: 10.1016/j.lungcan.2021.08.011. Epub 2021 Aug 27.
5
Safety of Tumor Treating Fields (TTFields) Applied to the Torso.应用于躯干的肿瘤治疗电场（TTFields）的安全性。
Front Oncol. 2021 Jun 24;11:670809. doi: 10.3389/fonc.2021.670809. eCollection 2021.
6
Tumour treating fields therapy for glioblastoma: current advances and future directions.肿瘤电场治疗胶质母细胞瘤：当前进展和未来方向。
Br J Cancer. 2021 Feb;124(4):697-709. doi: 10.1038/s41416-020-01136-5. Epub 2020 Nov 4.
7
Correlation of Tumor Treating Fields Dosimetry to Survival Outcomes in Newly Diagnosed Glioblastoma: A Large-Scale Numerical Simulation-Based Analysis of Data from the Phase 3 EF-14 Randomized Trial.肿瘤治疗电场剂量学与新诊断胶质母细胞瘤生存结局的相关性：基于 3 期 EF-14 随机试验数据的大规模数值模拟分析。
Int J Radiat Oncol Biol Phys. 2019 Aug 1;104(5):1106-1113. doi: 10.1016/j.ijrobp.2019.04.008. Epub 2019 Apr 23.
8
Tumor-Treating Fields: A Fourth Modality in Cancer Treatment.肿瘤电场治疗：癌症治疗的第四种模式。
Clin Cancer Res. 2018 Jan 15;24(2):266-275. doi: 10.1158/1078-0432.CCR-17-1117. Epub 2017 Aug 1.
9
Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields).使用肿瘤治疗电场（TTFields）确定癌细胞的最佳抑制频率。
J Vis Exp. 2017 May 4(123):55820. doi: 10.3791/55820.