He Mingxia, Jiang Yuxia, Wu Haiying, Xu Xiaofeng, Jiang Huifang
Department of Hematology, Tongde Hospital of Zhejiang Province, Hangzhou, P.R. China.
Department of Hematology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, P.R. China.
Medicine (Baltimore). 2025 Jan 10;104(2):e41195. doi: 10.1097/MD.0000000000041195.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infections are a severe complication resulting from granulocyte deficiency following chemotherapy for hematologic malignancies and have a high mortality rate. However, reports of disseminated organ infections secondary to bloodstream infections are rare.
We report 2 cases of patients with acute lymphoblastic leukemia who both developed CRKP bloodstream infections during the granulocyte deficiency stage following chemotherapy, with 1 case of secondary bacterial liver abscess and 1 case of secondary septic arthritis.
Based on the results of drug sensitivity testing, both patients were treated with ceftazidime-avibactam, and the infections were rapidly and effectively controlled without significant adverse effects.
Ceftazidime-avibactam exhibited satisfactory efficacy and safety in the 2 cases of disseminated organ infection secondary to CRKP bloodstream infection following chemotherapy for acute lymphoblastic leukemia.
耐碳青霉烯类肺炎克雷伯菌（CRKP）血流感染是血液系统恶性肿瘤化疗后粒细胞缺乏引起的严重并发症，死亡率很高。然而，继发于血流感染的播散性器官感染报告很少。
我们报告2例急性淋巴细胞白血病患者，均在化疗后的粒细胞缺乏阶段发生CRKP血流感染，其中1例继发细菌性肝脓肿，1例继发化脓性关节炎。
根据药敏试验结果，2例患者均接受头孢他啶-阿维巴坦治疗，感染迅速有效得到控制，且无明显不良反应。
头孢他啶-阿维巴坦在2例急性淋巴细胞白血病化疗后CRKP血流感染继发播散性器官感染病例中显示出令人满意的疗效和安全性。
